|
rs1036819
|
|
|
0.720 |
GeneticVariation |
BEFREE |
ESR1 rs17847075 genotype AG in the dominant model (P = 0.008) or heterozygous model (P = 0.045), ESR1 rs2234693 genotype TC in the dominant model (P = 0.008) or heterozygous model (P = 0.028), and ZFAT rs1036819 genotype CC and allele C in the recessive model (P = 0.042) were significantly associated with POP risk in Xinjiang woman.
|
31270553 |
2020 |
|
rs1036819
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The two most significant rQTL (rs8027714 and rs1036819) for ptau/Aβ42 are on different chromosomes and both are strong hits for pelvic organ prolapse.
|
30153862 |
2018 |
|
rs1950626
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In race-specific analysis of grade 0 vs 2-3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62-2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96-4.48, p = 2.6x10-7) were associated with POP in HPs.
|
26545240 |
2015 |
|
rs2236479
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our study suggests lack of association between DNA polymorphisms rs2236479 of COL18A1 and rs2862296 of LOXL-4 with advanced POP in this population.
|
29532123 |
2018 |
|
rs28573326
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In race-specific analysis of grade 0 vs 2-3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62-2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96-4.48, p = 2.6x10-7) were associated with POP in HPs.
|
26545240 |
2015 |
|
rs8027714
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The two most significant rQTL (rs8027714 and rs1036819) for ptau/Aβ42 are on different chromosomes and both are strong hits for pelvic organ prolapse.
|
30153862 |
2018 |
|
rs1800255
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Polymorphism rs1800255 from COL3A1 gene was not a risk factor for pelvic organ prolapse.
|
31041498 |
2020 |
|
rs1800255
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The previously found statistically significant association between the rs1800255, COL3A1 2209 G>A polymorphism as measured with PCR-RFLP and POP could no longer be demonstrated.
|
24760181 |
2014 |
|
rs1800255
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The metaanalysis suggests that collagen type 3 alpha 1 (COL3A1) rs1800255 genotype AA is associated with pelvic organ prolapse (odds ratio, 4.79; 95% confidence interval, 1.91-11.98; P = .001) compared with the reference genotype GG in populations of Asian and Dutch women.
|
24721264 |
2014 |
|
rs1136410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the poly(ADP-ribose) polymerase-1 Val762Ala polymorphism is associated with a decreased risk of advanced pelvic organ prolapse.
|
23760440 |
2014 |
|
rs12237222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs12237222 with the highest RegulomeDB score 1a appeared to be the key SNP in haplotypes associated with POP.
|
26347886 |
2015 |
|
rs12589592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We revealed significant associations of tag SNPs rs2018736 and rs12589592 with POP.
|
24917111 |
2014 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GSTP1 Ile105Val polymorphism is a protective factor against advanced POP.
|
24582550 |
2014 |
|
rs17435959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We support the view that the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of POP.
|
26419737 |
2015 |
|
rs17576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study shows that the polymorphism of matrix metalloproteinase-9 rs17576 may be associated with pelvic organ prolapse.
|
20144500 |
2010 |
|
rs17847075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ESR1 rs17847075 genotype AG in the dominant model (P = 0.008) or heterozygous model (P = 0.045), ESR1 rs2234693 genotype TC in the dominant model (P = 0.008) or heterozygous model (P = 0.028), and ZFAT rs1036819 genotype CC and allele C in the recessive model (P = 0.042) were significantly associated with POP risk in Xinjiang woman.
|
31270553 |
2020 |
|
rs2018736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We revealed significant associations of tag SNPs rs2018736 and rs12589592 with POP.
|
24917111 |
2014 |
|
rs2228480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association with pelvic organ prolapse was seen in individual studies for estrogen receptor alpha (ER-α) rs2228480 GA, COL3A1 exon 31, chromosome 9q21 (heterogeneity logarithm of the odds score 3.41) as well as 6 single nucleotide polymorphisms identified by a genome-wide association study.
|
24721264 |
2014 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ESR1 rs17847075 genotype AG in the dominant model (P = 0.008) or heterozygous model (P = 0.045), ESR1 rs2234693 genotype TC in the dominant model (P = 0.008) or heterozygous model (P = 0.028), and ZFAT rs1036819 genotype CC and allele C in the recessive model (P = 0.042) were significantly associated with POP risk in Xinjiang woman.
|
31270553 |
2020 |
|
rs2249492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP.
|
31663982 |
2020 |
|
rs2281968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association between COL14A1 SNPs (rs4870723, rs2305600, and rs2305598; P = 0.013, 0.019, and 0.028, respectively), a COL5A1 SNP (rs3827852; P = 0.016), and COL4A2 SNPs (rs76425569, rs388222, and rs2281968; P = 0.049 for the three, and rs445348, P = 0.040) and POP, respectively.
|
31663982 |
2020 |
|
rs2305598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association between COL14A1 SNPs (rs4870723, rs2305600, and rs2305598; P = 0.013, 0.019, and 0.028, respectively), a COL5A1 SNP (rs3827852; P = 0.016), and COL4A2 SNPs (rs76425569, rs388222, and rs2281968; P = 0.049 for the three, and rs445348, P = 0.040) and POP, respectively.
|
31663982 |
2020 |
|
rs2305600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association between COL14A1 SNPs (rs4870723, rs2305600, and rs2305598; P = 0.013, 0.019, and 0.028, respectively), a COL5A1 SNP (rs3827852; P = 0.016), and COL4A2 SNPs (rs76425569, rs388222, and rs2281968; P = 0.049 for the three, and rs445348, P = 0.040) and POP, respectively.
|
31663982 |
2020 |
|
rs2305603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP.
|
31663982 |
2020 |
|
rs2586488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP.
|
31663982 |
2020 |