|
rs7859727
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similarly, a higher risk of IS was also observed in the combined genotypes of the rs10757278 AG/GG and rs9333358 AG/GG (95% CI: 1.34-2.83, P < 0.001).
|
31810024 |
2020 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we are unable to identify any association between rs10757278 and IS.
|
31055994 |
2019 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additionally, rs1075</span>7278 polymorphism was also significantly correlated with an increased risk of IS in Caucasians.
|
30962266 |
2019 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There were no statistically significant differences in the distribution of genotypes and alleles of the rs10757278 polymorphism between groups of children with arterial ischemic stroke and controls.
|
28778720 |
2017 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This study is the first one to demonstrate that the rs10757278-GG genotype, the rs1537378-C allele, and rs1333047-TT genotype are associated with IS in Chinese Han populations.
|
25724239 |
2015 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Overall, the summary odds ratio of IS was 1.11 (95% CI: 1.07-1.15, P<10(-5)) for rs10757278.
|
24625579 |
2014 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
ANCOVA and multivariable logistic regression modeling were performed to determine independent genetic associations between the key chromosome 9p21.3 SNP, rs10757278, and ischemic stroke by comparing allele frequencies between 229 patients with stroke or TIA and an equal number of matched nonstroke controls, adjusting for other risk factors.
|
21088391 |
2011 |
|
rs10757278
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Meta-analysis confirmed that both rs1537378 and rs10757278 are risk factors for ischemic stroke (ORs, 1.09 [P=0.0014] and 1.11 [P=0.001], respectively).
|
20395606 |
2010 |
|
rs2383207
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS.
|
31757599 |
2020 |
|
rs2383207
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The ANRIL variants rs2383207 and rs1333049 were significantly associated with the risk of IS among males but not females in the Chinese Han population.
|
29881905 |
2018 |
|
rs2383207
|
|
|
0.040 |
GeneticVariation |
BEFREE |
CDKN2A/CDKN2B SNP rs2383207 is independently associated with ischemic stroke in indigenous West African men.
|
28716248 |
2017 |
|
rs2383207
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Chromosome 9p21 SNPs were also associated with risk of ischaemic stroke in African Americans (rs1333040, OR 0.65, P = 0.023; rs1333042, OR 0.55, P = 0.070; rs2383207, OR 0.55, P = 0.070).
|
22882272 |
2013 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Further subgroup analyses by ethnicity revealed that rs2383206, rs10757274 and rs10757278 variants were all significantly correlated with an increased risk of IS in Asians.
|
30962266 |
2019 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Loci rs2383206 and rs10757274 may increase susceptibility to IS.
|
31055994 |
2019 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Loci rs2383206 and rs10757274 may increase susceptibility to IS.
|
31055994 |
2019 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Further subgroup analyses by ethnicity revealed that rs2383206, rs10757274 and rs10757278 variants were all significantly correlated with an increased risk of IS in Asians.
|
30962266 |
2019 |
|
rs10757274
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In a hospital based case control study, we investigated the association of cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and two genetic variants (rs10757274 and rs2383206) on chromosome region 9p21 with ischemic stroke in Chinese Hans.
|
19559344 |
2009 |
|
rs2383206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition, the GG/GA genotypes of rs2383206 and rs3731245 was associated with an increased risk of large vessel subtype and small vessel subtype of ischemic stroke, respectively, with ORs of 2.09 (95%CI 1.30-3.37, p=0.002) and 1.63 (95%CI 1.06-2.51, p=0.026), respectively.
|
19559344 |
2009 |
|
rs1333040
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
|
rs1333042
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
|
rs4977574
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
|
rs1537378
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study is the first one to demonstrate that the rs10757278-GG genotype, the rs1537378-C allele, and rs1333047-TT genotype are associated with IS in Chinese Han populations.
|
25724239 |
2015 |
|
rs1333040
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Chromosome 9p21 SNPs were also associated with risk of ischaemic stroke in African Americans (rs1333040, OR 0.65, P = 0.023; rs1333042, OR 0.55, P = 0.070; rs2383207, OR 0.55, P = 0.070).
|
22882272 |
2013 |
|
rs1333042
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Chromosome 9p21 SNPs were also associated with risk of ischaemic stroke in African Americans (rs1333040, OR 0.65, P = 0.023; rs1333042, OR 0.55, P = 0.070; rs2383207, OR 0.55, P = 0.070).
|
22882272 |
2013 |