| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.050 | GeneticVariation | BEFREE | The results showed that the 861G allele of 5-HTR1B SNP rs6296 could significantly increase the risk of ADHD (C)R=1.09, 95% CI: 1.01-1.18); the 5-HTR2C gene rs518147 (OR=1.69, 95% CI: 1.38-2.07) and rs3813929 (OR = 1.57, 95% CI: 1.25-1.97) were all associated with the risk of ADHD. | 30074224 | 2018 |
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0.050 | GeneticVariation | BEFREE | Taking into account the well-known sexual dimorphic effect observed in serotonergic system characteristics, we differentially tested the influence of HTR1B SNPs (rs11568817, rs130058, rs6296 and rs13212041) on ADHD susceptibility and on its major comorbidities according to sex. | 28923721 | 2017 |
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0.050 | GeneticVariation | BEFREE | We measured neural activation during stop-signal task performance in adolescents with ADHD (N = 185), their unaffected siblings (N = 111), and healthy controls (N = 124), and investigated the relationship of two serotonin gene polymorphisms (the rs6296 SNP of the HTR1B gene and HTTLPR variants of the 5-HTT gene) with the neural correlates of response inhibition. | 26428549 | 2015 |
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0.050 | GeneticVariation | BEFREE | We used the transmission disequilibrium test (TDT) and haplotype analysis to investigate the A-161T and G861C polymorphisms in the 5-HT1B receptor gene in ADHD trios from the Chinese Han population. | 15578608 | 2005 |
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0.050 | GeneticVariation | BEFREE | We tested for linkage disequilibrium between the 5-HT1B G861C polymorphism and ADHD in 115 families using the transmission disequilibrium test (TDT). | 12556913 | 2003 |
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0.010 | GeneticVariation | BEFREE | As for the comorbidities evaluated, after correction for multiple tests, significant associations were observed for both rs11568817 and rs130058 with substance use disorders (P<sub>corr</sub> = 0.009 and P<sub>corr</sub> = 0.018, respectively) and for rs11568817 with nicotine dependence (P<sub>corr</sub> = 0.025) in men with ADHD. | 28923721 | 2017 |
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0.010 | GeneticVariation | BEFREE | As for the comorbidities evaluated, after correction for multiple tests, significant associations were observed for both rs11568817 and rs130058 with substance use disorders (P<sub>corr</sub> = 0.009 and P<sub>corr</sub> = 0.018, respectively) and for rs11568817 with nicotine dependence (P<sub>corr</sub> = 0.025) in men with ADHD. | 28923721 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | Taking into account the well-known sexual dimorphic effect observed in serotonergic system characteristics, we differentially tested the influence of HTR1B SNPs (rs11568817, rs130058, rs6296 and rs13212041) on ADHD susceptibility and on its major comorbidities according to sex. | 28923721 | 2017 |