|
rs1048220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to determine the association of three BDNF variants (rs6265, rs1048218 and rs1048220) with Malaysian MDD patients.
|
30677092 |
2019 |
|
rs10835210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
|
rs11030101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks.
|
29310728 |
2018 |
|
rs11030101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Association analyses of patients with MDD and controls showed that 6 SNPs were associated with MDD (rs12273539, rs11030103, rs6265, rs28722151, rs41282918, and rs11030101) and 2 haplotypes in different blocks (one including Val66, another near exon VIIIh) were significantly associated with MDD.
|
19414708 |
2009 |
|
rs11030101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
rs10835210 CA and rs11030101 AT genotype frequencies were higher in BD and schizophrenia patients than in healthy and MD subjects.
|
22094229 |
2012 |
|
rs11030101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of the present study was to examine the role of two BDNF gene polymorphisms (rs11030101 and rs61888800) in relation to the response to selective serotonin reuptake inhibitor medication in 106 patients of Finnish origin suffering from major depression.
|
23250003 |
2013 |
|
rs12273539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analyses of patients with MDD and controls showed that 6 SNPs were associated with MDD (rs12273539, rs11030103, rs6265, rs28722151, rs41282918, and rs11030101) and 2 haplotypes in different blocks (one including Val66, another near exon VIIIh) were significantly associated with MDD.
|
19414708 |
2009 |
|
rs1401635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 21 SNPs, TAL1 rs2984618 obesity-risk allele was associated with a higher risk of major depressive disorder (P = 1.79 × 10(-4), adjusted for age, sex, BMI, and ethnicity), and BDNF rs1401635 demonstrated significant ethnic-dependent association with major depressive disorder (OR = 0.88; 95% CI, 0.80-0.97; P = .01 in non-Europeans and OR = 1.11; 95% CI, 1.02-1.20; P = .02 in Europeans; Pinteraction = 2.73 × 10(-4)).
|
26717541 |
2015 |
|
rs1415125856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After all, according to these findings, -1438A/G, 102T/C, and 5-HTTLPR polymorphisms could be considered as promising pharmacogenetic biomarkers in CIT/SERT treatment in major depressive disorder (MDD) patients to avoid the occurrence of SD.
|
31792367 |
2019 |
|
rs2030324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
|
rs61888800
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of the present study was to examine the role of two BDNF gene polymorphisms (rs11030101 and rs61888800) in relation to the response to selective serotonin reuptake inhibitor medication in 106 patients of Finnish origin suffering from major depression.
|
23250003 |
2013 |
|
rs61888800
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks.
|
29310728 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline).
|
21338649 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.
|
20674983 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia.
|
25956254 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019).
|
20033742 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males.
|
22033217 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder.
|
17036259 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.
|
25745134 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome.
|
23165919 |
2013 |