Gene: BDNF ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. 17401528

2007
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD. 26078197

2015
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD). 31308724

2019
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949

2015
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD. 20016225

2010
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia. 21129438

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls. 22965830

2013
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression. 22844024

2012
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender. 19589373

2010
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls. 22194899

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response. 26976307

2016
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants. 19668114

2009
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD. 22883353

2012
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. 29778546

2018
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780). 23157339

2013
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity. 25044977

2014
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our results suggested that 5-HTTLPR, may be associated with the susceptibility of MDD in an overdominant mode, and there may be a significant interaction between 5-HTTLPR and BDNF (rs6265) polymorphisms in relation to MDD. 27212180

2016
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans. 17632285

2007
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels. 28848102

2017
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. 20195291

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. 20167454

2010
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. 18852698

2010
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892

2019
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD. 19699537

2009
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE None of the eight SNPs, including the rs6265, were significantly associated with MDD after permutation correction. 21188787

2011