|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.
|
22883353 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780).
|
23157339 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val</span>66Met</span> polymorphism and child adversity.
|
25044977 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggested that 5-HTTLPR, may be associated with the susceptibility of MDD in an overdominant mode, and there may be a significant interaction between 5-HTTLPR and BDNF (rs6265) polymorphisms in relation to MDD.
|
27212180 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
|
17632285 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk.
|
20195291 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder.
|
20167454 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women.
|
18852698 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that SNPs rs6265, rs10835210 and rs2030324 of the BDNF gene are unlikely to play a critical role in the pathogenesis of MDD.
|
19699537 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the eight SNPs, including the rs6265, were significantly associated with MDD after permutation correction.
|
21188787 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients.
|
19493959 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.
|
22585743 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting.
|
23184535 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The gene-environment combination of PRKCG rs3745406 C allele, BDNF rs6265 G allele and high level of negative life events (C-G-HN) was significantly associated with MDD (OR, 5.97; 95% CI, 2.71-13.15).
|
26921055 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism may play a salient role in structural alterations of the hippocampus in older adults with MDD.
|
21218562 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.
|
29432620 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention.
|
18721847 |
2008 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our two-center study was to determine how the BDNF Val66Met</span> polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD.
|
23341118 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine whether the polymorphisms of BDNF (rs6265) and NTRK2 (rs1387923, rs2769605 and rs1565445) genes confer risk for TRD in major depressive disorder (MDD), a total of 948 MDD patients were recruited in a 12-week, multicenter, prospective longitudinal study.
|
23137999 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, there was no significant difference in normalized HCV between 5HTTLPR diallelic and triallelic classifications or between the BDNF Val66Met</span> genotypes in MDD patients, although there was a relationship between BDNF Val66Met and ICV.
|
21692988 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |