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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
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31308724 |
2019 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study indicated that having the BDNF rs6265 allele (A) increase the risk of developing MDD in the Malaysian population suggesting a possible role of BDNF in the etiology of the disorder.
|
30677092 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
|
31308724 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.
|
29432620 |
2018 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed.
|
29414128 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism.
|
28656803 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.
|
29432620 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed.
|
29414128 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels.
|
28848102 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD.
|
29387021 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response.
|
26976307 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggested that 5-HTTLPR, may be associated with the susceptibility of MDD in an overdominant mode, and there may be a significant interaction between 5-HTTLPR and BDNF (rs6265) polymorphisms in relation to MDD.
|
27212180 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The gene-environment combination of PRKCG rs3745406 C allele, BDNF rs6265 G allele and high level of negative life events (C-G-HN) was significantly associated with MDD (OR, 5.97; 95% CI, 2.71-13.15).
|
26921055 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population.
|
27212180 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response.
|
26976307 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia.
|
25956254 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.
|
25745134 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.
|
26078197 |
2015 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.
|
25510949 |
2015 |