| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.060 | GeneticVariation | BEFREE | The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning. | 28608854 | 2017 |
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0.060 | GeneticVariation | BEFREE | The G-allele of rs6295 is known to be associated with aspects of major depression and migraine. | 23333373 | 2013 |
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0.060 | GeneticVariation | BEFREE | The most replicated findings are the associations between rs6295 (HTR1A gene) G allele or G/G genotype and rs6311 (HTR2A gene) A allele or A/A genotype and MD or depressive symptoms. | 23547754 | 2013 |
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0.060 | GeneticVariation | BEFREE | In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed. | 22727709 | 2012 |
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0.060 | GeneticVariation | BEFREE | Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. | 19897250 | 2009 |
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0.060 | GeneticVariation | BEFREE | On the other hand, we detected an association between rs6295 and MDD in the meta-analysis (P(Z)=0.0327). | 19730445 | 2009 |
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0.010 | GeneticVariation | BEFREE | We found an association between rs878567 and Japanese MDD</span> patients in the allele-wise analysis, but the significance of this association did not remain after Bonferroni's correction. | 19730445 | 2009 |