Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In addition, there were no clear interactions of the ADH1B with ALDH2 Glu487Lys and MTHFR C677T with regard to the risk of colorectal adenoma. 21517275

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk. 18322814

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found. 17089070

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom). 16783607

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status. 17087956

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Neither MTHFR C677T nor ALDH2 showed a measurable association with colorectal adenoma. 16108833

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No association was observed between MTHFR C677T genotype and colorectal adenomas. 15941973

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Almost all of seven studies of colorectal adenoma have found no association between C677T polymorphism and adenoma, but the 677TT genotype seems to be related to increased risk when folate status is poor. 16128738

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States). 15286469

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas. 12690011

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk. 10919734

2000

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found. 17089070

2007

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom). 16783607

2006

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status. 17087956

2006

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE We examined folate and alcohol intake and genetic polymorphisms in methylenetetrahydrofolate reductase [MTHFR 667-->T (ala-->val) and MTHFR 1298A-->C (gln-->ala)] (associated with reduced MTHFR activity) and in alcohol dehydrogenase 3 [ADH3 (2-2) associated with decreased alcohol catabolism] in relation to risk of colorectal adenoma in the Health Professionals Follow-Up Study. 14578131

2003