|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms in XRCC1, Arg194Trp and Arg399Gln, have been repeatedly associated with risk for and outcome of numerous types of cancer treated with radio- and chemotherapy.
|
20044627 |
2009 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For Arg(399)Gln (10 studies, 3729 cases, 3927 controls), the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR 0.95, 95% CI 0.82 to 1.10; P = 0.48).
|
18336890 |
2008 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For Arg399Gln, the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR = 0.92, 95% CI, 0.71-1.19; P = 0.51).
|
19034980 |
2008 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.
|
16030121 |
2005 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied.
|
16038584 |
2005 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.
|
16030121 |
2005 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association between cancer risk and the APE1/APEX1 Asp148Glu and XRCC1 Arg280His polymorphisms.
|
16221808 |
2005 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Growing evidence suggests that the polymorphism of DNA base excision repair gene XRCC1 Arg399Gln is associated with altered DNA repair proficiency and subsequent cancer susceptibility; however, no evidence is available for malignant lymphoma.
|
15104288 |
2004 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we have shown that three nsSNPs, which were predicted to have functional consequences (XRCC1-R399Q, XRCC3-T241M, XRCC1-R280H), were already found to be associated with cancer risk.
|
15159313 |
2004 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
|
12618003 |
2003 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
|
12618003 |
2003 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer.
|
12496039 |
2002 |
|
rs3810378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five polymorphisms of the XRCC1 gene (rs3213403, rs1799778, rs1001581, rs3213282, and rs3810378) were genotyped by TaqMan in 234 patients with larynx cancer and 230 age- and sex-matched controls without cancer.
|
24956286 |
2014 |