Gene: HRAS ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104894229
rs104894229
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Additionally, the specific p.G12R NRAS mutation in this case is a common somatic mutation in cancer cells, and analysis of previously reported NRAS-RASopathy cases suggests that mutations at traditionally oncogenic codons are associated with elevated cancer risk not present with mutations at other sites. 31697451

2020
dbSNP: rs104894230
rs104894230
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Although mutations in known driver genes typically occurred early in cancer evolution, we also identified later subclonal "actionable" mutations, including BRAF (V600E), IDH1 (R132H), PIK3CA (E545K), EGFR (L858R), and KRAS (G12D), which may compromise the efficacy of targeted therapy approaches. 25877892

2015
dbSNP: rs727503094
rs727503094
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Although mutations in known driver genes typically occurred early in cancer evolution, we also identified later subclonal "actionable" mutations, including BRAF (V600E), IDH1 (R132H), PIK3CA (E545K), EGFR (L858R), and KRAS (G12D), which may compromise the efficacy of targeted therapy approaches. 25877892

2015
dbSNP: rs104894229
rs104894229
HRAS ; LRRC56
0.020 GeneticVariation BEFREE GeLC-MRM detected KRAS mutant variants (G12D, G13D, G12V, G12S) in a panel of cancer cell lines. 22671702

2012
dbSNP: rs104894230
rs104894230
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Analysis of the major phenotypic features by mutation suggests a potential correlation between malignancy risk and genotype, which is highest for patients with an uncommon (G12A) substitution. 16443854

2006
dbSNP: rs727503094
rs727503094
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Analysis of the major phenotypic features by mutation suggests a potential correlation between malignancy risk and genotype, which is highest for patients with an uncommon (G12A) substitution. 16443854

2006
dbSNP: rs766801436
rs766801436
HRAS ; LRRC56
0.010 GeneticVariation BEFREE We next expanded our analysis with 276 OSCC and 134 L/P-SCC sample data from The Cancer Genome Atlas (TCGA dataset). 29884412

2018
dbSNP: rs112690925
rs112690925
HRAS ; LRRC56
0.010 GeneticVariation BEFREE For HRAS, 2 SNP alleles (rs112690925, rs7939028) that created CpG's occurred significantly less frequently in the cancer data sets than in the general SNP databases (e.g., rs7939028, p < 0.0002, in comparison with AllSNPs(142)). 27074591

2016
dbSNP: rs7939028
rs7939028
HRAS ; LRRC56
0.010 GeneticVariation BEFREE For HRAS, 2 SNP alleles (rs112690925, rs7939028) that created CpG's occurred significantly less frequently in the cancer data sets than in the general SNP databases (e.g., rs7939028, p < 0.0002, in comparison with AllSNPs(142)). 27074591

2016