|
rs1049216
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The results did not support an association between CASP3 rs1049216 and rs6948 polymorphisms and cancer risk.
|
30368918 |
2018 |
|
rs1049216
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These data indicate that through upregulating the expression of caspase-3, the TT genotype of caspase-3 rs1049216 can be associated with not only the risk of cervical cancer but also the progression of this cancer.
|
28114230 |
2017 |
|
rs1049216
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meta-analysis results showed that the homozygote (CC) of rs2705897 in the CASP-3 gene is positively associated with cancer susceptibility [odds ratio (OR) = 4.36, 95% confidence interval (CI) = 1.26-15.11, P = 0.02], while the C allele and C carrier (TC+CC) of rs1049216 are negatively associated with cancer risk (OR = 0.81, 95%CI = 0.69-0.95, P = 0.01; OR = 0.78, 95%CI = 0.63-0.97, P = 0.02, respectively).
|
23765963 |
2013 |
|
rs2705897
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The findings suggested that the rs2705897 variant significantly decreased the risk of cancer in heterozygous codominant (OR, 0.80; 95% CI, 0.67-0.94; P = 0.009; AC vs AA), dominant (OR, 0.81; 95% CI, 0.69-0.95; P = 0.009; AC+CC vs AA), overdominant (OR, 0.80; 95% CI, 0.68-0.95; P = 0.01; AC vs CC+AA), and allele (OR, 0.85; 95% CI, 0.74-0.97; P = 0.02; C vs A) models.
|
30368918 |
2018 |
|
rs4647603
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs4647603 variant significantly increased the risk of cancer in an overdominant (OR, 1.44; 95% CI, 1.03-2.01; P = 0.03; AG vs AA+GG) inheritance model.
|
30368918 |
2018 |
|
rs2705897
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Meta-analysis results showed that the homozygote (CC) of rs2705897 in the CASP-3 gene is positively associated with cancer susceptibility [odds ratio (OR) = 4.36, 95% confidence interval (CI) = 1.26-15.11, P = 0.02], while the C allele and C carrier (TC+CC) of rs1049216 are negatively associated with cancer risk (OR = 0.81, 95%CI = 0.69-0.95, P = 0.01; OR = 0.78, 95%CI = 0.63-0.97, P = 0.02, respectively).
|
23765963 |
2013 |
|
rs4647603
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The G allele and G carrier of rs4647603 (A/G) in CASP-3 had positive associations with cancer susceptibility (OR = 1.69, 95%CI = 1.37-2.09, P < 0.001; OR = 1.93, 95%CI = 1.26-2.93, P = 0.002, respectively).
|
23765963 |
2013 |
|
rs113420705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a meta-analysis aiming to inspect the association between CASP3 rs1049216 T>C, rs12108497 C>T, rs4647603 G>A, rs4647602 C>A, rs6948 T>G, rs2705897 A>C, and rs113420705 G>A polymorphisms and cancer risk.
|
30368918 |
2018 |
|
rs4647602
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding the rs4647602 variant, the findings revealed that this variant was associated with protection against cancer in homozygous codominant (OR, 0.67; 95% CI, 0.56-0.80; P < 0.00001; AA vs CC), dominant (OR, 0.84; 95% CI, 0.73-0.96; P = 0.009; AC+AA vs CC), recessive (OR, 0.70; 95% CI, 0.61-0.79; P < 0.00001; AA vs AC+CC), and allele (OR, 0.81; 95% CI, 0.75-0.88; P = 0.00001; A vs C) models.
|
30368918 |
2018 |
|
rs6948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results did not support an association between CASP3 rs1049216 and rs6948 polymorphisms and cancer risk.
|
30368918 |
2018 |
|
rs12108497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, when stratifying by age, sex, smoking, drinking, HBV carrier status, and family history of cancer, we found that the variant genotypes (CT + TT) of the CASP3 rs12108497 were associated with a significant increased risk of HCC among smoking individuals (adjusted OR = 2.31, 95 % CI = 1.11-4.79).
|
26758428 |
2016 |
|
rs2705901
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG genotype of rs2705901 in the caspase-3 gene was significantly associated with increased cancer risk compared with the CC genotype (odds ratio, 2.25; 95% CI, 1.03-4.95).
|
19531679 |
2009 |