|
rs4624820
|
|
|
0.810 |
GeneticVariation |
BEFREE |
However, three SNPs for adult height individually showed association with testicular germ cell tumour (rs4624820: OR = 1.47, 95% CI: 1.41-1.55, p = 2.7 × 10<sup>-57</sup> ; rs12228415: OR = 1.17, 95% CI: 1.11-1.22, p = 3.1 × 10<sup>-10</sup> ; rs7568069: OR = 1.13, 95% CI: 1.07-1.18, p = 1.1 × 10<sup>-6</sup> ).
|
28804972 |
2017 |
|
rs9905704
|
|
|
0.810 |
GeneticVariation |
BEFREE |
In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26; P = 1.11 × 10(-8)), 7p22.3 in MAD1L1 (OR = 1.21, 95% CI = 1.14-1.29; P = 5.59 × 10(-9)), 16q22.3 in RFWD3 (OR = 1.26, 95% CI = 1.18-1.34; P = 5.15 × 10(-12)) and 17q22 (rs9905704: OR = 1.27, 95% CI = 1.18-1.33; P = 4.32 × 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
|
23666239 |
2013 |
|
rs995030
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We found significant differences in the KITLG GG_rs995030 genotype in TM (P = 0.01) and TGCT patients (P = 0.0005) compared with the control.
|
30027931 |
2019 |
|
rs995030
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We found that TGCT risk was increased more than twofold per copy of the major G allele and A allele in KITLG rs995030 and rs4471514 (odds ratio (OR)=2.38, 95% confidence interval (95% CI)=1.81-3.12; OR=2.43, 95% CI=1.86-3.17 respectively), and homozygotes for the risk allele had a sevenfold increased risk of TGCT.
|
22194441 |
2012 |
|
rs11705932
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13 (rs4561483, GSPT1, P=1.6 × 10(-8)) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10(-9)).
|
26503584 |
2015 |
|
rs4561483
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13 (rs</span>4561483, GSPT1, P=1.6 × 10(-8)) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10(-9)).
|
26503584 |
2015 |
|
rs55637647
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13 (rs4561483, GSPT1, P=1.6 × 10(-8)) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10(-9)).
|
26503584 |
2015 |
|
rs7107174
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13 (rs4561483, GSPT1, P=1.6 × 10(-8)) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10(-9)).
|
26503584 |
2015 |
|
rs7221274
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26; P = 1.11 × 10(-8)), 7p22.3 in MAD1L1 (OR = 1.21, 95% CI = 1.14-1.29; P = 5.59 × 10(-9)), 16q22.3 in RFWD3 (OR = 1.26, 95% CI = 1.18-1.34; P = 5.15 × 10(-12)) and 17q22 (rs9905704: OR = 1.27, 95% CI = 1.18-1.33; P = 4.32 × 10(-13) and rs7221274: OR = 1.20, 95% CI = 1.12-1.28; P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
|
23666239 |
2013 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Forty-one TGCT tumors were used to investigate hypermethylation of RASSF1A and MGMT gene and mutations of KRAS codon 12/13, BRAF V600E and cKIT exon 17 mutations.
|
31653608 |
2020 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Forty-one TGCT tumors were used to investigate hypermethylation of RASSF1A and MGMT gene and mutations of KRAS codon 12/13, BRAF V600E and cKIT exon 17 mutations.
|
31653608 |
2020 |
|
rs17198432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated allele and genotype frequencies for KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876), BAK1 (rs210138), BMP7 (rs388286), TGFBR3 (rs12082710), and HOXD (rs17198432) in 142 TGCT patients, 137 TM patients, and 153 fertile men (control group).
|
30027931 |
2019 |
|
rs12228415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, three SNPs for adult height individually showed association with testicular germ cell tumour (rs4624820: OR = 1.47, 95% CI: 1.41-1.55, p = 2.7 × 10<sup>-57</sup> ; rs12228415: OR = 1.17, 95% CI: 1.11-1.22, p = 3.1 × 10<sup>-10</sup> ; rs7568069: OR = 1.13, 95% CI: 1.07-1.18, p = 1.1 × 10<sup>-6</sup> ).
|
28804972 |
2017 |
|
rs7568069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, three SNPs for adult height individually showed association with testicular germ cell tumour (rs4624820: OR = 1.47, 95% CI: 1.41-1.55, p = 2.7 × 10<sup>-57</sup> ; rs12228415: OR = 1.17, 95% CI: 1.11-1.22, p = 3.1 × 10<sup>-10</sup> ; rs7568069: OR = 1.13, 95% CI: 1.07-1.18, p = 1.1 × 10<sup>-6</sup> ).
|
28804972 |
2017 |
|
rs2075789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The hMSH5 C85T allele is not associated with the occurrence of TGCT.
|
27370712 |
2016 |
|
rs11202586
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 23 SNPs investigated in the combined study, one SNP in PTEN (rs11202586) remained associated with TGCT risk after adjusting for multiple testing (OR = 1.16, 95% CI = 1.06-1.28, P bonf = 0.040).
|
23639623 |
2013 |
|
rs10137185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-parent analysis, the markers rs12434245 and rs10137185 were associated with a reduced risk of TGCT (OR = 0.66 and 0.72, respectively; both FDRs <5%), whereas rs2978381 and rs12435857 were associated with an increased risk of TGCT (OR = 1.21 and 1.19, respectively; both FDRs <5%).
|
22402210 |
2012 |
|
rs10146204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the combined case-parent/case-control analysis, rs12435857 and rs10146204 were associated with an increased risk of TGCT (OR = 1.15 and 1.13, respectively; both FDRs <5%), whereas rs10137185 was associated with a reduced risk of TGCT (OR = 0.79, FDR <5%).
|
22402210 |
2012 |
|
rs12434245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-parent analysis, the markers rs12434245 and rs10137185 were associated with a reduced risk of TGCT (OR = 0.66 and 0.72, respectively; both FDRs <5%), whereas rs2978381 and rs12435857 were associated with an increased risk of TGCT (OR = 1.21 and 1.19, respectively; both FDRs <5%).
|
22402210 |
2012 |
|
rs12435857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-parent analysis, the markers rs12434245 and rs10137185 were associated with a reduced risk of TGCT (OR = 0.66 and 0.72, respectively; both FDRs <5%), whereas rs2978381 and rs12435857 were associated with an increased risk of TGCT (OR = 1.21 and 1.19, respectively; both FDRs <5%).
|
22402210 |
2012 |
|
rs2414099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T alleles of the rs2414099, rs8025374 and rs3751592 SNPs were associated with an increased risk of TGCT (OR = 1.30, 1.30 and 1.21, respectively; all FDRs <5%).
|
22402210 |
2012 |
|
rs2978381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-parent analysis, the markers rs12434245 and rs10137185 were associated with a reduced risk of TGCT (OR = 0.66 and 0.72, respectively; both FDRs <5%), whereas rs2978381 and rs12435857 were associated with an increased risk of TGCT (OR = 1.21 and 1.19, respectively; both FDRs <5%).
|
22402210 |
2012 |
|
rs3751592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T alleles of the rs2414099, rs8025374 and rs3751592 SNPs were associated with an increased risk of TGCT (OR = 1.30, 1.30 and 1.21, respectively; all FDRs <5%).
|
22402210 |
2012 |
|
rs4471514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we analyzed the link between KITLG, TGCT, and spermatogenic disruption by performing an association study between the KITLG markers rs995030 and rs4471514 and 426 TGCT cases and 614 controls with normal and abnormal sperm count.
|
22194441 |
2012 |
|
rs8025374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T alleles of the rs2414099, rs8025374 and rs3751592 SNPs were associated with an increased risk of TGCT (OR = 1.30, 1.30 and 1.21, respectively; all FDRs <5%).
|
22402210 |
2012 |