|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
OPRM1 A118G, a functional human mu-opioid receptor (MOR) polymorphism, is associated with drug dependence and altered stress responsivity in humans as well as altered MOR signaling.
|
30027498 |
2018 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change (Asn40Asp) in the extracellular portion of the receptor, has been implicated in alcoholism as well as in drug addiction, pain sensitivity and stress response, and in animal and human studies relates to the alcohol-dependent phenotype as well as to the treatment response to the µ-opioid antagonist naltrexone.
|
23543091 |
2014 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug addiction.
|
22744787 |
2012 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opioid function and, consequently, has been suggested to contribute to individual variability in pain management and drug addiction.
|
20074870 |
2010 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive.
|
19528658 |
2009 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions.
|
16046395 |
2005 |
|
rs324420
|
|
|
0.020 |
GeneticVariation |
BEFREE |
As conclusion, because drug addiction is a multi-step process and a preventable disease, our results indicate that the FAAH C385A SNP is one of the most promising candidates for individuals who are at higher risk for alcohol problems.
|
24407958 |
2014 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis.
|
24279859 |
2013 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction.
|
20655300 |
2010 |
|
rs1042363
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among all markers, SNP2 (rs1042363) at exon 9 or SNP6 (rs1800759) at the promoter showed the greatest degree of HWD, among patients with either alcohol dependence or drug dependence.
|
16237392 |
2006 |
|
rs324420
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we investigated the relationship of the FAAH P129T variant to a number of linked single nucleotide polymorphisms to establish a haplotyping system, calculate the estimated age and origin of the FAAH 385 C-->A mutation and evaluate its association with clinically significant drug addiction in a case control study.
|
16972078 |
2006 |
|
rs1042363
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that: (i) the genotypes of SNP2 (rs1042363) were significantly associated with alcohol dependence and drug dependence (mainly cocaine dependence), and the genotypes of SNP3 (rs1126671) were also significantly associated with alcohol dependence and (ii) one seven-variant haplotype and one diplotype were significantly associated with alcohol dependence and other seven-variant diplotypes were significantly associated with drug dependence (including cocaine and opioid dependence).
|
16220108 |
2005 |
|
rs17228602
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population.
|
31129131 |
2019 |
|
rs17228616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population.
|
31129131 |
2019 |
|
rs3735451
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of rs3735451 on drug addiction risk were related to drug-using time (<i>p</i> < 0.05).
|
31799230 |
2019 |
|
rs4646437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For men, rs3735451, rs4646440, and rs4646437 had strong relationship with decreased risk of drug addiction (<i>p</i> < 0.05).
|
31799230 |
2019 |
|
rs4646440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For men, rs3735451, rs4646440, and rs4646437 had strong relationship with decreased risk of drug addiction (<i>p</i> < 0.05).
|
31799230 |
2019 |
|
rs1255388379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OPRM1 A118G, a functional human mu-opioid receptor (MOR) polymorphism, is associated with drug dependence and altered stress responsivity in humans as well as altered MOR signaling.
|
30027498 |
2018 |
|
rs1047383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between rs1047383 in the PLCB1 gene and drug dependence that was replicated in an independent sample (663 cases and 667 controls).
|
28860459 |
2017 |
|
rs441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05).
|
28052001 |
2017 |
|
rs4646778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05).
|
28052001 |
2017 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05).
|
28052001 |
2017 |
|
rs886205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05).
|
28052001 |
2017 |
|
rs1650420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, SNPs GABRB3 rs7165224; DBI rs12613135; GAD1 SNPs rs2058725, rs1978340, rs2241164; and GRIN2A rs1650420 were previously reported in associations with drug addiction or related phenotypes.
|
26277529 |
2016 |
|
rs3743484
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In genetic model analyses, the minor C allele of rs3743484 in CYP1A2 was associated with a reduced risk of drug addiction based on analysis using codominant and additive models (p = 0.027 dominant model; p =0.038 additive model).
|
27257124 |
2016 |