|
rs11154027
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
The authors have identified previously undescribed genetic predictors of tendinopathy in elite team sports athletes, notably rs11154027, rs4362400, and rs10263021.
|
31615970 |
2019 |
|
rs11154027
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Carriage of 1+ variant alleles for rs11154027 (odds ratio = 2.11; 95% confidence interval, 1.07-4.19, P = 1.01 × 10-6) or rs4362400 (odds ratio = 1.98; 95% confidence interval, 1.05-3.73, P = 9.6 × 10-6) was associated with a higher risk of tendinopathy, whereas an opposite effect was found for rs10263021 (odds ratio = 0.42; 95% confidence interval, 0.20-0.91], P = 4.5 × 10-6).
|
31615970 |
2019 |
|
rs57224706
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy.
|
28358823 |
2017 |
|
rs60713544
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy.
|
28358823 |
2017 |
|
rs12722
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TC inferred haplotype (rs12722, rs3196378) was found to be overrepresented (global p = 0.008) in the South African tendinopathy group compared with all other haplotypes.
|
18443036 |
2009 |
|
rs12722
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy.
|
19042922 |
2009 |
|
rs4362400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of 1+ variant alleles for rs11154027 (odds ratio = 2.11; 95% confidence interval, 1.07-4.19, P = 1.01 × 10-6) or rs4362400 (odds ratio = 1.98; 95% confidence interval, 1.05-3.73, P = 9.6 × 10-6) was associated with a higher risk of tendinopathy, whereas an opposite effect was found for rs10263021 (odds ratio = 0.42; 95% confidence interval, 0.20-0.91], P = 4.5 × 10-6).
|
31615970 |
2019 |
|
rs11225395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs1144393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs1799750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs2252070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs587778430
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The KDR (-604C>T, 1192G>A and 1719T>A) haplotypes CGA and CAT were associated with decreased tendinopathy risk (OR: 0.46, 95% CI: 0.21-0.99 and OR: 0.23, 95% CI: 0.07-0.76, respectively).
|
27930691 |
2016 |
|
rs2761884
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association between BMP4 rs2761884 (p=0.03) and tendinopathy was observed.
|
24661680 |
2015 |
|
rs900379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FGF3 TGGTA haplotype showed a tendency of association with tendinopathy (p=0.05), and so did FGF10 rs900379.
|
24661680 |
2015 |
|
rs9505888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no difference in genotype distributions between control and tendinopathy groups for either the THBS2 variants rs9505888, rs6422747 and rs9283850, or the COMP variants rs730079 and rs28494505 in the SA and AUS populations.
|
23875975 |
2014 |
|
rs3196378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TC inferred haplotype (rs12722, rs3196378) was found to be overrepresented (global p = 0.008) in the South African tendinopathy group compared with all other haplotypes.
|
18443036 |
2009 |
|
rs650108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ATG haplotype (rs679620, rs591058, and rs650108) was under-represented in the tendinopathy group when compared to the control group (41% vs 53%, p = 0.038).
|
19042922 |
2009 |
|
rs679620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy.
|
19042922 |
2009 |