|
rs10433937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SERPINA1 Pi*S variant conferred an increased risk of developing liver fibrosis, while SERPINA1 Pi*Z and HSD17B13 rs10433937 were not associated with liver fibrosis or cirrhosis of different aetiology.
|
31517326 |
2019 |
|
rs12075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis.
|
30970632 |
2019 |
|
rs1682111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs17580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations of SERPINA1 Z (rs28929474) and S (rs17580) alleles with age at CFLD onset and the development of CFLD-related complications (severe liver disease with cirrhosis, portal hypertension, esophageal varices) were analyzed.
|
30739910 |
2019 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TNF-α rs1800629 polymorphism is a potential genetic-susceptibility factor for HCV related cirrhosis and HCC progression.
|
30204505 |
2019 |
|
rs2066844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive patients with cirrhosis in 2 academic medical centers were included and genotyped for the NOD2 variants p.R702W, p.G908R, and c.3020insC.
|
30702490 |
2019 |
|
rs2241880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis.
|
31484215 |
2019 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations of SERPINA1 Z (rs28929474) and S (rs17580) alleles with age at CFLD onset and the development of CFLD-related complications (severe liver disease with cirrhosis, portal hypertension, esophageal varices) were analyzed.
|
30739910 |
2019 |
|
rs4646437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analysis, rs4646437 genotype CC and cirrhosis were significant, independent factors associated with grade ≥1 ALT elevation (odds ratio, 2.83 and 1.88; p = 0.040 and 0.045, respectively).
|
31291311 |
2019 |
|
rs510432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analyses, rs510432 allele A-containing genotypes (AA+GA) were independently associated with cirrhosis in comparison to chronic hepatitis (OR 1.927, 95%CI 1.011-3.017, P = 0.032).
|
30907204 |
2019 |
|
rs548234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the dominant model, HCC patients had significantly higher frequencies of rs548234 genotypes CC + TC than cirrhosis patients (P = .009).
|
31729038 |
2019 |
|
rs6721961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specimens from patients diagnosed with cirrhosis caused by ALD were genotyped for three NFE2L2 single nucleotide polymorphisms (SNP) (SNPs: rs35652124, rs4893819, and rs6721961).
|
31340446 |
2019 |
|
rs675520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with rs675520 AG/GG genotypes had decreased odds of having cirrhosis (F4) and advanced fibrosis (FIB-4 ≥ 3.25 and APRI≥1.5) [adjusted Odd Ratio (aOR) = 0.30 (p = 0.025), aOR = 0.20 (p = 0.014), and aOR = 0.34 (p = 0.017), respectively] and lower levels of FIB-4 and APRI [adjusted arithmetic mean ratio (aAMR) = 0.76 (p = 0.003) and aAMR = 0.72 (p = 0.006), respectively].
|
30336268 |
2019 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6834314 was significantly associated with increased steatosis but decreased inflammation, ballooning, Mallory-Denk bodies, and liver enzyme levels in 768 adult Caucasians with biopsy-proven NAFLD and with cirrhosis in the general population.
|
30415504 |
2019 |
|
rs843645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs843720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04).
|
31124313 |
2019 |
|
rs1054690270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations.
|
28635613 |
2018 |
|
rs2071746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis.
|
29877949 |
2018 |
|
rs6897932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariable analysis, the rs6897</span>932 T allele was related to a higher increase of LSM values during follow-up (adjusted AMR = 1.27 (95%CI = 1.13; 1.42); p<0.001) and higher odds of progression to advanced fibrosis [adjusted OR = 4.46 (95%CI = 1.87; 10.62); p = 0.001], and progression to c</span>irrhosis [adjusted OR = 3.92 (95%CI = 1.30; 11.77); p = 0.015].
|
29742149 |
2018 |
|
rs8021276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs8021276 polymorphism was also associated with down-regulation of AT3 mRNA expression and increasing AFB1-DNA adducts in liver tissues with cirrhosis.
|
29937988 |
2018 |
|
rs1041740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although rs3844942 showed no associations with complications of cirrhosis, we observed a significant association between rs1041740 and the presence of ascites and SBP in the discovery cohort of patients with cirrhosis.
|
28403123 |
2017 |
|
rs10945859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among these SNPs, CT genotype of rs10945859 was found to have a significant association towards the clinical progression of chronic HCV infection to cirrhosis alone (OR = 1.850; 95% C. I.
|
27740515 |
2017 |
|
rs11614913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that rs2292832 and rs11614913 were associated with risk of HBV infection, viral clearance and cirrhosis+HCC, whereas rs2910164 was associated with proneness to HBV infection, and ability to clear the virus.
|
28685993 |
2017 |
|
rs121918664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three of the four variants (T726M, A1062T, and V1090M) were previously observed in patients with other telomere diseases (severe aplastic anemia, acute myeloid leukemia, and cirrhosis).
|
28813500 |
2017 |
|
rs12980275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of this study suggest that IL28B rs12979860 TT or rs12980275 GG may play an important protective role against the development of advanced fibrosis and even cirrhosis.
|
28253210 |
2017 |