|
rs1127354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs7270101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.
|
12865278 |
2003 |
|
rs12304647
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A Cox relative hazards model with adjustments for age, gender, HBeAg status, and cirrhosis revealed that rs12304647A>C retained its association with HCC in a codominant model (relative hazards [RH] = 1.14, P = 0.05) and in a recessive model (RH = 1.44, P = 0.03).
|
24248733 |
2014 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%).
|
10673304 |
2000 |
|
rs641738
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers.
|
26850495 |
2016 |
|
rs1346044973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel TERT variant, A243V, was identified in a 65-year-old male with advanced HCC and cirrhosis secondary to chronic hepatitis C virus (HCV) and alcohol ingestion, but direct assay measurements in vitro did not detect modulation of telomerase enzymatic activity or processivity.
|
28813500 |
2017 |
|
rs7254880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant allelic association was found between rs7254880 in ZNF699 and alcohol-related cirrhosis (n=292), using cases with no biopsy evidence of liver disease (n=314) as controls (P=0.013).
|
26368818 |
2015 |
|
rs4074
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001).
|
24260493 |
2013 |
|
rs8021276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs8021276 polymorphism was also associated with down-regulation of AT3 mRNA expression and increasing AFB1-DNA adducts in liver tissues with cirrhosis.
|
29937988 |
2018 |
|
rs58542926
|
|
|
0.030 |
GeneticVariation |
BEFREE |
After further conditioning for steatosis and necroinflammation, the E167K variant remained associated with cirrhosis (OR, 3.15; 95% CI: 1.60-5.99; P < 0.001).
|
25820484 |
2015 |
|
rs1012068
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p = 0.0104) and CT for SNP rs5998152 (OR = 1.932; 95% CI 1.276-2.925; p = 0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively.
|
25551790 |
2014 |
|
rs5998152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p = 0.0104) and CT for SNP rs5998152 (OR = 1.932; 95% CI 1.276-2.925; p = 0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively.
|
25551790 |
2014 |
|
rs3844942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although rs3844942 showed no associations with complications of cirrhosis, we observed a significant association between rs1041740 and the presence of ascites and SBP in the discovery cohort of patients with cirrhosis.
|
28403123 |
2017 |
|
rs1041740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although rs3844942 showed no associations with complications of cirrhosis, we observed a significant association between rs1041740 and the presence of ascites and SBP in the discovery cohort of patients with cirrhosis.
|
28403123 |
2017 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the PNPLA3 rs738409 G allele has been associated with the risk of steatosis in CHB patients, no association between this polymorphism and the risk of cirrhosis was seen.
|
29218813 |
2018 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among Caucasians, C282Y heterozygotes were more likely to have bridging fibrosis or cirrhosis (44% versus 21% [P = 0.05]) and stainable hepatic iron (50% versus 16% [P = 0.011]) compared with patients with other genotypes.
|
17680648 |
2007 |
|
rs10945859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among these SNPs, CT genotype of rs10945859 was found to have a significant association towards the clinical progression of chronic HCV infection to cirrhosis alone (OR = 1.850; 95% C. I.
|
27740515 |
2017 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An elevated SF >1000 mg/l [corrected] is associated with an increased risk of cirrhosis and mortality in C282Y homozygotes.Conversely, a SF <1000 µg/l is associated with a very low likelihood of cirrhosis, making liver biopsy unnecessary among C282Y homozygotes in the absence of concomitant risk factors for liver disease.
|
23985001 |
2013 |
|
rs7975232
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis.
|
31682785 |
2020 |
|
rs2736098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association Between the Telomerase rs2736098_TT Genotype and a Lower Risk of Chronic Hepatitis B and Cirrhosis in Chinese Males.
|
28300824 |
2017 |
|
rs2229113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection.
|
15729365 |
2005 |