| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.020 | GeneticVariation | BEFREE | We have shown previously that a known xenoestrogen, bisphenol A (BPA), activates a tumor-derived AR mutant (T877A), leading to androgen-independent prostate cancer cell proliferation. | 15665279 | 2005 |
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|
0.020 | GeneticVariation | BEFREE | We also demonstrate that the observed loss in ligand specificity between the wild-type (wt) AR and the T877A mutant AR associated with androgen-independent prostate cancer is reflected in decreased BE values (i.e., higher binding affinity) for the antiandrogen pharmaceutical hydroxyflutamide and for several nonandrogenic endogenous steroids, most notably cortisol, corticosterone, 17beta-estradiol, progesterone, and 17alpha-hydroxyprogesterone. | 14680380 | 2003 |
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|
0.010 | GeneticVariation | BEFREE | Therefore, we initially studied the effect of rs61552325 on androgen-independent prostate cancer cell metastasis. | 28422721 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | Due to the expression of ABCG2 in the prostate, together with the purported role of dietary carcinogens and steroids in the development and progression of prostate cancer, 311 individuals were genotyped for the ABCG2 C421A SNP, 170 patients with androgen-independent prostate cancer (AIPC) and 141 'healthy' controls. | 18710444 | 2008 |
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0.010 | GeneticVariation | BEFREE | However, we found that, among men with the homozygous CC wild-type (but not CT/TT) of the HIF-1alpha P582S, higher IGFBP-3 levels (>/= vs. <median) were associated with a 28% (95% CI, 0.55-0.95; P(interaction) = 0.01) lower risk of overall CaP and a 53% (0.25-0.88; P(interaction) = 0.11) lower risk of metastatic and fatal CaP. | 17624927 | 2007 |
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0.010 | GeneticVariation | BEFREE | Neither the P582S nor the A588T polymorphism was associated with risk of overall or metastatic/fatal CaP. | 17624927 | 2007 |