rs5743890
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Leukocyte telomere length (LTL), <i>MUC5B</i> rs35705950 and <i>TOLLIP</i> rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248).
|
30635297 |
2019 |
rs5743890
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We measured two common single-nucleotide polymorphisms associated with IPF (MUC5B rs35705950 and TOLLIP rs5743890) and telomere length in peripheral blood leucocytes, and assessed their associations with chronic hypersensitivity pneumonitis risk, survival, and clinical, radiographic, and pathological features.
|
28648751 |
2017 |
rs5743890
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
|
24429156 |
2013 |
rs5743890
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Individuals who developed IPF despite having the protective TOLLIP minor allele of rs5743890 carried an increased mortality risk (meta-analysis with fixed-effect model: hazard ratio 1·72 [95% CI 1·24-2·38]; p=0·0012).
|
24429156 |
2013 |
rs5743890
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
|
24429156 |
2013 |
rs5743894
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
|
24429156 |
2013 |
rs5743894
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
|
24429156 |
2013 |
rs111521887
|
|
G |
0.700 |
GeneticVariation |
GWASDB |
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
|
24429156 |
2013 |
rs3750920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NAC may be an efficacious therapy for individuals with IPF with an rs3750920 (TOLLIP) TT genotype, but it was associated with a trend toward harm in those with a CC genotype.
|
26331942 |
2015 |