Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation BEFREE Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. 19404200

2009
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation BEFREE N34S SPINK1 represents the major genetic risk factor in TCP. 19077465

2009
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation BEFREE The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013). 18706099

2008
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation BEFREE As PRSS1 mutations are absent in TCP and the N34S SPINK1 mutation is proposed to play a modifier role, these variants may be critical as a trigger for cationic trypsinogen activation. 16492714

2006
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation BEFREE TCP is highly associated with the SPINK1 N34S mutation. 12360463

2002
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation UNIPROT Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. 12011155

2002
dbSNP: rs17107315
rs17107315
SPINK1
0.750 GeneticVariation UNIPROT SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. 12187509

2002
dbSNP: rs148954387
rs148954387
SPINK1
G 0.700 CausalMutation CLINVAR

dbSNP: rs777418530
rs777418530
CRISPLD2
0.020 GeneticVariation BEFREE N34S SPINK1 represents the major genetic risk factor in TCP. 19077465

2009
dbSNP: rs12338
rs12338
CTSB
0.020 GeneticVariation BEFREE No statistically significant association of the SNPs was observed with TCP or FCPD or between carriers and non-carriers of N34S SPINK1 and L26V CTSB mutations. 18706099

2008
dbSNP: rs747940576
rs747940576
CTSB
0.020 GeneticVariation BEFREE The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013). 18706099

2008
dbSNP: rs776941569
rs776941569
CTSB
0.020 GeneticVariation BEFREE No statistically significant association of the SNPs was observed with TCP or FCPD or between carriers and non-carriers of N34S SPINK1 and L26V CTSB mutations. 18706099

2008
dbSNP: rs1223231582
rs1223231582
PRSS1
0.020 GeneticVariation BEFREE As PRSS1 mutations are absent in TCP and the N34S SPINK1 mutation is proposed to play a modifier role, these variants may be critical as a trigger for cationic trypsinogen activation. 16492714

2006
dbSNP: rs12338
rs12338
CTSB
0.020 GeneticVariation BEFREE This significant association of Leu26Val with TCP was replicated in another cohort (OR 2.10 (95% CI 1.56-2.84); p = 0.013). 16492714

2006
dbSNP: rs747940576
rs747940576
CTSB
0.020 GeneticVariation BEFREE As PRSS1 mutations are absent in TCP and the N34S SPINK1 mutation is proposed to play a modifier role, these variants may be critical as a trigger for cationic trypsinogen activation. 16492714

2006
dbSNP: rs776941569
rs776941569
CTSB
0.020 GeneticVariation BEFREE This significant association of Leu26Val with TCP was replicated in another cohort (OR 2.10 (95% CI 1.56-2.84); p = 0.013). 16492714

2006
dbSNP: rs1223231582
rs1223231582
PRSS1
0.020 GeneticVariation BEFREE TCP is highly associated with the SPINK1 N34S mutation. 12360463

2002
dbSNP: rs777418530
rs777418530
CRISPLD2
0.020 GeneticVariation BEFREE TCP is highly associated with the SPINK1 N34S mutation. 12360463

2002
dbSNP: rs8099917
rs8099917 		0.010 GeneticVariation BEFREE Under favorable conditions such as treatment-naïve/prior relapse and interleukin-28B (IL28B) TT allele (rs8099917), the SVR rates of the Spx group were significantly higher than those of the non-Spx/moderate TCP (60-79 × 10(9) /L) groups (91.3% vs 50.0% and 93.8% vs 37.5%, respectively; both P < 0.05). 24731162

2014
dbSNP: rs61734659
rs61734659
PRSS2
0.010 GeneticVariation BEFREE G191R was detected in 1 TCP patient (0.6%) compared to 13 controls (1.6%; OR 0.27, 95% CI 0.03-2.1; p = 0.33). 19077465

2009
dbSNP: rs748405415
rs748405415
PRSS2
0.010 GeneticVariation BEFREE G191R was detected in 1 TCP patient (0.6%) compared to 13 controls (1.6%; OR 0.27, 95% CI 0.03-2.1; p = 0.33). 19077465

2009
dbSNP: rs557826746
rs557826746
TCF7L2
0.010 GeneticVariation BEFREE No statistically significant association of the SNPs was observed with TCP or FCPD or between carriers and non-carriers of N34S SPINK1 and L26V CTSB mutations. 18706099

2008
dbSNP: rs7903146
rs7903146
TCF7L2
0.010 GeneticVariation BEFREE The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013). 18706099

2008
dbSNP: rs768051473
rs768051473
PRSS1
0.010 GeneticVariation BEFREE This significant association of Leu26Val with TCP was replicated in another cohort (OR 2.10 (95% CI 1.56-2.84); p = 0.013). 16492714

2006