|
rs10842262
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Collectively, the rs2477686, rs6080550, and rs10842262 may indeed be the genetic risk factors for NOA, which requires further investigation using larger independent sets of samples in different ethnic populations.
|
30863997 |
2019 |
|
rs12097821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs2477686
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A previous Chinese genome-wide single-nucleotide polymorphism (SNP) association studies have identified four SNPs (rs12097821 in PRMT6 gene, rs2477686 in PEX10 gene, rs6080550 in SIRPA-SIRPG, and rs10842262 in SOX5 gene) as being significantly associated with risk factors for nonobstructive azoospermia (NOA).
|
30863997 |
2019 |
|
rs10842262
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association studies did not support the association of rs12097821 and rs2477686 with NOA for both genotype and allele distributions, but rs10842262 in the SOX5 gene was significantly associated with NOA (chi square = 9.31; P = 0.0095 and chi square = 9.27; P = 0.0023, respectively).
|
24648396 |
2014 |
|
rs12097821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association studies did not support the association of rs12097821 and rs2477686 with NOA for both genotype and allele distributions, but rs10842262 in the SOX5 gene was significantly associated with NOA (chi square = 9.31; P = 0.0095 and chi square = 9.27; P = 0.0023, respectively).
|
24648396 |
2014 |
|
rs2477686
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association studies did not support the association of rs12097821 and rs2477686 with NOA for both genotype and allele distributions, but rs10842262 in the SOX5 gene was significantly associated with NOA (chi square = 9.31; P = 0.0095 and chi square = 9.27; P = 0.0023, respectively).
|
24648396 |
2014 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To confirm this association, the distribution of the single-nucleotide polymorphism C677T was investigated in idiopathic infertile Algerian patients with nonobstructive azoospermia (NOA) or severe oligoasthenoteratozoospermia (OAT).
|
22928696 |
2012 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
rs1052482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that two SNVs (rs1727130 and rs1052482) located in the 3'-UTR region may be associated with the NOA phenotype.
|
31115363 |
2020 |
|
rs1727130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that two SNVs (rs1727130 and rs1052482) located in the 3'-UTR region may be associated with the NOA phenotype.
|
31115363 |
2020 |
|
rs1391626331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study revealed a novel stopgain mutation c.G992A (p.W331X) in TACR3 which expanded the mutation spectrum of TACR3 in Chinese NOA infertile men and advanced our understanding of the genetic susceptibility to NOA.
|
30390321 |
2019 |
|
rs161870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five genetic variants showed positive correlations with NOA: MTRR c.537T>C (rs161870), odds ratios (OR), 3.686, 95% confidence interval (CI), 1.228-11.066; MTRR, c.1049A>G (rs162036), OR, 3.686, 95% CI, 1.228-11.066; PIWIL1, c.1580G>A (rs1106042), OR, 4.737, 95% CI, 1.314-17.072; TAF4B, c.1815T>C (rs1677016), OR, 3.599, 95% CI, 1.255-10.327; and SOX10 c.927T>C (rs139884), OR, 3.192, 95% CI, 1.220-8.353.
|
31377750 |
2019 |
|
rs4997052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The novel variant rs4997052 identified in our study can explain another approximately 0.66% of the phenotypic variances of NOA.
|
30502936 |
2019 |
|
rs6080550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the rs2477686, rs6080550, and rs10842262 may indeed be the genetic risk factors for NOA, which requires further investigation using larger independent sets of samples in different ethnic populations.
|
30863997 |
2019 |
|
rs757689467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five genetic variants showed positive correlations with NOA: MTRR c.537T>C (rs161870), odds ratios (OR), 3.686, 95% confidence interval (CI), 1.228-11.066; MTRR, c.1049A>G (rs162036), OR, 3.686, 95% CI, 1.228-11.066; PIWIL1, c.1580G>A (rs1106042), OR, 4.737, 95% CI, 1.314-17.072; TAF4B, c.1815T>C (rs1677016), OR, 3.599, 95% CI, 1.255-10.327; and SOX10 c.927T>C (rs139884), OR, 3.192, 95% CI, 1.220-8.353.
|
31377750 |
2019 |
|
rs764088622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel USP26 variant p.R344W is associated with NOA probably through affecting AR function.
|
27089915 |
2016 |
|
rs10849753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs17431717 near SFRS9 and rs12046213 near SFRS4 were significantly associated with a decreased risk of NOA, whereas rs10849753 near SFRS9 and rs6103330 in SFRS6 were associated with an increased risk of NOA.
|
24661730 |
2014 |
|
rs1148247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of CREM gene variants suggested that haplotype CGTG of the SNPs, rs4934540, rs2295415, rs11592356, and rs1148247, exhibited significant protective effect against the occurrence of NOA (P = 0.001, OR = 0.659).
|
24943041 |
2014 |
|
rs12046213
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combined analysis of three promising SNPs (rs17431717, rs12046213, and rs6103330) showed that compared with individuals with "0-2" risk alleles, those carrying "3," "4," and "≥ 5" risk alleles had 1.22-, 1.38-, and 1.90-fold increased risk of NOA, respectively.
|
24661730 |
2014 |
|
rs2295415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CREM variants rs4934540 and rs2295415 conferred susceptibility to nonobstructive azoospermia risk in the Chinese population.
|
24943041 |
2014 |
|
rs4934540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CREM variants rs4934540 and rs2295415 conferred susceptibility to nonobstructive azoospermia risk in the Chinese population.
|
24943041 |
2014 |
|
rs6103330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combined analysis of three promising SNPs (rs17431717, rs12046213, and rs6103330) showed that compared with individuals with "0-2" risk alleles, those carrying "3," "4," and "≥ 5" risk alleles had 1.22-, 1.38-, and 1.90-fold increased risk of NOA, respectively.
|
24661730 |
2014 |
|
rs189037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia.
|
23993922 |
2013 |
|
rs3129878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected variants at human leukocyte antigen (HLA) regions that were independently associated with NOA (HLA-DRA, rs3129878, p(combine) = 3.70 × 10(-16), odds ratio [OR] = 1.37; C6orf10 and BTNL2, rs498422, p(combine) = 2.43 × 10(-12), OR = 1.42).
|
22541561 |
2012 |
|
rs498422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected variants at human leukocyte antigen (HLA) regions that were independently associated with NOA (HLA-DRA, rs3129878, p(combine) = 3.70 × 10(-16), odds ratio [OR] = 1.37; C6orf10 and BTNL2, rs498422, p(combine) = 2.43 × 10(-12), OR = 1.42).
|
22541561 |
2012 |