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rs12150220
|
|
T |
0.810 |
SusceptibilityMutation |
CLINVAR |
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rs12150220
|
|
|
0.810 |
GeneticVariation |
UNIPROT |
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rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The objective of this study was to ascertain if the disease-associated 1858T allele was also associated with generalised (nonsegmental) vitiligo and so the frequencies of the PTPN22 1858C/T alleles were investigated in 165 English patients with generalised vitiligo and 304 ethnically matched control subjects.
|
16015369 |
2005 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo.
|
16464986 |
2006 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase non-receptor (LYP, PTPN22) gene has been reported to be associated with several autoimmune disorders including Graves' disease, type 1 diabetes, rheumatoid arthritis and vitiligo.
|
16893384 |
2006 |
|
rs1805008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C478T, one of the MC1R SNPs studied in 108 fair-skinned vitiligo patients and in 70 fair-skinned healthy control individuals, showed a significant difference (P=0.0262, odds ratio [95% confidence interval]=3.6 [0.0046-0.1003]) in allele frequency between the two groups: the allele frequency was higher in the control group, suggesting protection against vitiligo.
|
18282185 |
2008 |
|
rs2269577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we also found suggestive epistatic effect between rs2269577 and HLA-DRB1*07 allele on the development of vitiligo (p = 0.033).
|
19543371 |
2009 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While there was no association with vitiligo overall, the meta-analysis showed significant association of SNP rs231775 in that subgroup of vitiligo patients who also had other concomitant autoimmune diseases.
|
19175525 |
2009 |
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rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although the PTPN22 1858C/T variant has been reported to play a role in increasing the risk of vitiligo in Caucasian patients, it does not appear to play a similar role in the Jordanian population, though a larger cohort of patients might be needed to confirm such a conclusion.
|
20560680 |
2010 |
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rs1534284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated that both MYG1 promoter polymorphism -119C/G and Arg4Gln polymorphism in the mitochondrial signal of Myg1 have a functional impact on the regulation of the MYG1 gene and promoter polymorphism (-119C/G) is related with suspectibility for actively progressing vitiligo.
|
20377893 |
2010 |
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rs2267641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele T of tag SNP rs4618569 was associated with an increased risk for vitiligo in the family trios (P=0.002, odds ratio (OR)=5.27; 95% confidence interval (CI)=1.59-17.40), whereas allele C of tag SNP rs2267641 was associated with an increased risk for vitiligo in both family-based and case-control populations (P=0.01, OR=3.47; 95% CI=1.22-9.17; P=0.04, OR=6.00; 95% CI=1.73-52.33, respectively).
|
20182441 |
2010 |
|
rs4618569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele T of tag SNP rs4618569 was associated with an increased risk for vitiligo in the family trios (P=0.002, odds ratio (OR)=5.27; 95% confidence interval (CI)=1.59-17.40), whereas allele C of tag SNP rs2267641 was associated with an increased risk for vitiligo in both family-based and case-control populations (P=0.01, OR=3.47; 95% CI=1.22-9.17; P=0.04, OR=6.00; 95% CI=1.73-52.33, respectively).
|
20182441 |
2010 |
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rs4744411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three susceptibility signals, represented by single-nucleotide polymorphisms (SNPs) rs6960920 in 7p13, rs734930 in 7q11, and rs4744411 in 9q22, were significantly associated with vitiligo and other autoimmune diseases.
|
19727120 |
2010 |
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rs6960920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three susceptibility signals, represented by single-nucleotide polymorphisms (SNPs) rs6960920 in 7p13, rs734930 in 7q11, and rs4744411 in 9q22, were significantly associated with vitiligo and other autoimmune diseases.
|
19727120 |
2010 |
|
rs71453838
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study demonstrated that both MYG1 promoter polymorphism -119C/G and Arg4Gln polymorphism in the mitochondrial signal of Myg1 have a functional impact on the regulation of the MYG1 gene and promoter polymorphism (-119C/G) is related with suspectibility for actively progressing vitiligo.
|
20377893 |
2010 |
|
rs734930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three susceptibility signals, represented by single-nucleotide polymorphisms (SNPs) rs6960920 in 7p13, rs734930 in 7q11, and rs4744411 in 9q22, were significantly associated with vitiligo and other autoimmune diseases.
|
19727120 |
2010 |
|
rs9468925
|
|
|
0.020 |
GeneticVariation |
BEFREE |
More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.
|
22125590 |
2011 |
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rs13208776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data shows that the variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients.
|
20965805 |
2011 |
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rs7758128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MHC) class II region, located near c6orf10-BTNL2 (rs7758128; P=8.14 × 10(-11)), a region that is also associated with generalized vitiligo susceptibility.
|
21326295 |
2011 |
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rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.
|
22846211 |
2012 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.
|
22846211 |
2012 |
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rs9468925
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Allele G of rs9468925 on HLA-C-HLA-B may be associated with a higher risk of vitiligo.
|
21951294 |
2012 |
|
rs10249788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the T allele of rs10249788 located in the promoter of the AHR gene is associated with a protective effect on vitiligo in Han Chinese populations.
|
22211302 |
2012 |
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rs2066853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, subjects with the combined (CT + TT)/GG genotype or T/G haplotype (rs10249788/rs2066853) showed a decreased risk for vitiligo (OR 0·57, 95% CI 0·37-0·87, P = 0·009 and OR 0·78, 95% CI 0·64-0·96, P = 0·033, respectively).
|
22211302 |
2012 |
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rs2243250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore intron 3 VNTR (IVS3) and -590 C/T (rs2243250) promoter polymorphisms in the IL4 gene and to correlate them with the IL4 transcript, serum IL-4 and IgE levels to achieve genotype-phenotype correlation in patients with vitiligo from Gujarat.
|
22512783 |
2012 |