|
rs12150220
|
|
|
0.810 |
GeneticVariation |
BEFREE |
With regard to vitiligo-associated autoimmune diseases, like Addison's disease, type 1 diabetes, or systemic lupus erythematosus, a decreased risk was detected for rs12150220 in the Caucasian subgroup under all models [<i>P</i><sub>association</sub> < 0.05, odds ratio (OR) < 1].
|
29152150 |
2017 |
|
rs12150220
|
|
T |
0.810 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs12150220
|
|
|
0.810 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We found that the allelic frequency of variants of PTPN22 (rs2476601) were significantly different between controls and cases showing a vitiligo risk in the South Indian Tamil population.
|
30008646 |
2018 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Meta-analysis of the PTPN22 1858 C/T polymorphism showed an association between the PTPN22 T allele and vitiligo in all subjects (OR = 1.507, 95 % CI = 1.320-1.720, p < 1.0 × 10(-8)) and in European group (OR = 1.530, 95 % CI = 1.339-1.748, p < 1.0 × 10(-8)), but not in Asians (OR = 0.482, 95 % CI = 0.152-1.530, p = 0.216).
|
23264102 |
2013 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although the PTPN22 1858C/T variant has been reported to play a role in increasing the risk of vitiligo in Caucasian patients, it does not appear to play a similar role in the Jordanian population, though a larger cohort of patients might be needed to confirm such a conclusion.
|
20560680 |
2010 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo.
|
16464986 |
2006 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase non-receptor (LYP, PTPN22) gene has been reported to be associated with several autoimmune disorders including Graves' disease, type 1 diabetes, rheumatoid arthritis and vitiligo.
|
16893384 |
2006 |
|
rs2476601
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The objective of this study was to ascertain if the disease-associated 1858T allele was also associated with generalised (nonsegmental) vitiligo and so the frequencies of the PTPN22 1858C/T alleles were investigated in 165 English patients with generalised vitiligo and 304 ethnically matched control subjects.
|
16015369 |
2005 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Determine serum homocysteine levels in vitiligo patients as well as the association between MTHFR (C677T, A1298C) and CBSgene polymorphisms and susceptibility to vitiligo in a sample of those populations.
|
31778995 |
2020 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Determine serum homocysteine levels in vitiligo patients as well as the association between MTHFR (C677T, A1298C) and CBSgene polymorphisms and susceptibility to vitiligo in a sample of those populations.
|
31778995 |
2020 |
|
rs1135216
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association.
|
28700671 |
2017 |
|
rs638893
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs638893 (a previously reported one) located upstream of DDX6 was also significantly associated with vitiligo (OR=1.25, 95% CI: 1.12-1.38, P=3.04×10<sup>-5</sup>).
|
28551095 |
2017 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1.
|
25896941 |
2015 |
|
rs3213758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the potential influence of 10 single-nucleotide polymorphisms (SNPs) at 18q21.31 (rs10503019), 4p16.1 (rs11940117), 3q28 (rs1464510), 14q12 (rs2273844), 12q13.2 (rs2456973), 16q12.2 (rs3213758), 10q25.3 (rs4353229), 3q13.33 (rs59374417), and 10p15.1 (rs706779 and rs7090530) on vitiligo with immune-related diseases in the Chinese Han population.
|
25952005 |
2015 |
|
rs1135216
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis.
|
25548428 |
2014 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that the rs11614913 C allele in miR-196a-2 confers potential protection against oxidative effects on human melanocytes through the modulation of the target gene, TYRP1, which may account for the decreased risk of vitiligo in this study population.
|
23433405 |
2013 |
|
rs3213758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A stronger association was suggested between the mutation in KIAA1005 (rs3213758</span>) and the segmental type compared to the non-segmental type of vitiligo.
|
23678272 |
2013 |
|
rs3761548
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs3761548 of FOXP3 gene in our population may be associated with susceptibility to vitiligo because of altered expression.
|
23498308 |
2013 |
|
rs3761548
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significantly increased vitiligo risk was associated with the rs2232365 GG [odds ratio (OR) 1·68, 95% confidence interval (CI) 1·17-2·39, P = 0·004] and rs3761548 AA (OR 1·82, 95% CI 1·10-3·01, P = 0·033) genotypes compared with the rs2232365 AA and rs3761548 CC genotypes.
|
23582052 |
2013 |
|
rs638893
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified three susceptibility loci, 12q13.2 (rs10876864, P(combined)=8.07 × 10(-12), odds ratio (OR)=1.18), 11q23.3 (rs638893, P(combined)=2.47 × 10(-9), OR=1.22), and 10q22.1 (rs1417210, P(combined)=1.83 × 10(-8), OR=0.88), and confirmed three previously reported loci for vitiligo, 3q28 (rs9851967, P(combined)=8.57 × 10(-8), OR=0.88), 10p15.1 (rs3134883, P(combined)=1.01 × 10(-5), OR=1.11), and 22q12.3 (rs2051582, P(combined)=2.12 × 10(-5), OR=1.14), in the Chinese Han population.
|
22951725 |
2013 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.
|
22846211 |
2012 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.
|
22846211 |
2012 |
|
rs9468925
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Allele G of rs9468925 on HLA-C-HLA-B may be associated with a higher risk of vitiligo.
|
21951294 |
2012 |
|
rs9468925
|
|
|
0.020 |
GeneticVariation |
BEFREE |
More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.
|
22125590 |
2011 |