|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001).
|
21714070 |
2011 |
|
rs3788266
|
|
|
0.020 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs1062613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs1106854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A mutation in intron four, rs1106854, was associated with BPAD, although a regulatory role for rs1106854 is unclear.
|
24817687 |
2014 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs1386482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs1386483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |
|
rs1386486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006).
|
19352219 |
2009 |
|
rs1469698992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs147837176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It therefore remains possible that Glu602Gly may be a rare cause of bipolar affective disorder.
|
10889530 |
2000 |
|
rs166508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One single SNP (rs166508) was associated with the BPAD phenotype (P = 0.0187).
|
23280964 |
2013 |
|
rs169068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to B</span>PAD with missense mutation Leu48Met (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs17110563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD.
|
17905754 |
2008 |
|
rs2076137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs2235349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association was observed for rs2235349 and rs2076137 with SCZ and ss16339163 with BPAD in case-control study.
|
15992519 |
2005 |
|
rs2251219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is strong evidence of association of rs2251219 with BP.
|
22560537 |
2012 |
|
rs2812393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs2839350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S100B single nucleotide polymorphisms (SNPs) rs2839350 (P = 0.022) and rs3788266 (P = 0.031) were significantly associated with BPAD.
|
17525977 |
2007 |
|
rs34608001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Danish population, association was suggested between silent SNP G573A and BPAD (P = 0.008).
|
12192619 |
2002 |
|
rs3771829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence.
|
24817687 |
2014 |
|
rs3831455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance.
|
22832903 |
2012 |
|
rs4290270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD.
|
19352219 |
2009 |