|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs4988483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the British population we found association to BPAD with missense mutation Leu48Met</span> (P = 0.003) and missense mutation Pro335Leu (P = 0.004).
|
12192619 |
2002 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
|
8493294 |
1993 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls.
|
8823764 |
1996 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi(2)=6.766, d.f.=1, P=0.009).
|
11027844 |
2000 |
|
rs707284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation.
|
21993442 |
2012 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs766288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs839523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation.
|
21993442 |
2012 |
|
rs9834970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35).
|
20414141 |
2010 |