rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The JAK2 (Janus kinase 2) V617F mutation is a well-known point mutation which is involved in the pathogenesis of IBD, and VTE.
|
31069840 |
2019 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The somatic mutation of JAK2 V617F and CALR mutations are less frequent causes of VTE, thus routine testing for these mutations is not recommended.
|
26304686 |
2017 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Individuals harboring JAK2 V617F mutation, regardless of MPN type, were at higher risk of VTE (OR=5.15, 95%CI: 1.16-22.90, P=0.024), mainly deep vein thrombosis (DVT).
|
25559461 |
2015 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
JAK2 V617F somatic mutation positives versus negatives had higher erythrocyte (P = 2 × 10(-5) ), thrombocyte (P = 2 × 10(-16) ), and leucocyte (P = 4 × 10(-9) ) counts, and had 2·7-/2·5-fold risk of cancer (prevalent/incident), 44-/28-fold risk of haematological cancer, 221-/97-fold risk of myeloproliferative cancer, 2·2-/1·2-fold risk of ischaemic heart disease, and 3·1-/1·0-fold risk of venous thromboembolism.
|
23116358 |
2013 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The JAK2(V617F)mutation is recurrent in polycythemia vera and essential thrombocythemia, which are myeloproliferative neoplasms frequently associated with arterial and venous thromboembolism.
|
20551270 |
2010 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Furthermore, patients affected by essential thrombocythemia who are carriers of the Janus kinase 2 Val617Phe mutation show a higher incidence of venous thromboembolism both before, and at the time of diagnosis, compared with noncarriers, and recent evidence of splanchnic and cerebral vein thrombosis in carriers of the Janus kinase 2 Val617Phe mutation has been reported.
|
18600099 |
2008 |
rs368927897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, coagulant factor V gene G1691A mutation and protein S deficiency constitute important genetic risk factors in patients with VTE in Eastern Algeria.
|
26304686 |
2017 |