|
rs770986654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, STAT3 mutations were identified in 18 of 36 patients with T-LGLL (50%), including Y640F (12/18, 66.7%), N647I (3/18, 16.7%), E638Q (1/18, 5.6%), I659L (1/18, 5.6%), and K657R (1/18, 5.6%).
|
29288042 |
2018 |
|
rs747639500
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This small subtype of T-LGL-L was recognized among rather young patients and was associated with D661Y mutations in the STAT3 gene SH2 domain.
|
27064362 |
2016 |
|
rs747639500
|
|
|
0.020 |
GeneticVariation |
BEFREE |
They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.
|
24689848 |
2014 |
|
rs770986654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.
|
24689848 |
2014 |
|
rs769031989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, STAT3 mutations were identified in 18 of 36 patients with T-LGLL (50%), including Y640F (12/18, 66.7%), N647I (3/18, 16.7%), E638Q (1/18, 5.6%), I659L (1/18, 5.6%), and K657R (1/18, 5.6%).
|
29288042 |
2018 |
|
rs587777648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, the patient harboring the K392R mutation developed T-cell large granular lymphocytic leukemia at age 14 years.
|
25349174 |
2015 |