|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our study indicate that the PHACTR1 rs9349379 polymorphism is associated with the increased risk for CAD in the female Chinese Han population.
|
30777881 |
2019 |
|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that rs9349379 polymorphism might affect individual susceptibility to CAD in both Caucasians and Asians.
|
31278837 |
2019 |
|
rs9349379
|
|
G |
0.760 |
GeneticVariation |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
This result suggests that rs9349379 may in part influence CAD by modulating the expression of intermediate PHACTR1 transcripts in endothelial or vascular smooth muscle cells found in hCA.
|
29884117 |
2018 |
|
rs9349379
|
|
A |
0.760 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
rs9349379
|
|
G |
0.760 |
GeneticVariation |
GWASCAT |
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
|
28714974 |
2017 |
|
rs9349379
|
|
G |
0.760 |
GeneticVariation |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.
|
27517945 |
2016 |
|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In primary human macrophages, we identified a novel expression quantitative trait locus (eQTL) specific for this short transcript, whereby the risk allele at CAD risk SNP rs9349379 is associated with reduced PHACTR1 expression, similar to the effect of an inflammatory stimulus.
|
27187934 |
2016 |
|
rs9349379
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The top variant, rs9349379, is intronic to PHACTR1, a risk locus for coronary artery disease, migraine, and cervical artery dissection.
|
27792790 |
2016 |
|
rs9349379
|
|
G |
0.760 |
GeneticVariation |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
rs12526453
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In the present study, we have shown that the rs12526453 single-nucleotide polymorphism of the PHACTR1 gene is significantly associated with a 50% reduction in the odds of CAD events in FH subjects.
|
29784573 |
2019 |
|
rs12526453
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Our results showed that the polymorphisms rs1252</span>6453 and rs11066301 are significantly associated with the CAD risk in multiple populations.
|
25123136 |
2014 |
|
rs12526453
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
rs12526453
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
rs9369640
|
|
C |
0.700 |
GeneticVariation |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
rs2026458
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CC genotype of rs2026458 was more prevalent in the controls than in patients with CAD compared with TT genotype (OR=0.548, 95% CI 0.351 to 0.856, p=0.008).
|
30777881 |
2019 |
|
rs2026458
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024).
|
27517945 |
2016 |