|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis.
|
29952962 |
2018 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population.
|
29118461 |
2017 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease.
|
25155309 |
2016 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.
|
26467378 |
2016 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease.
|
25155309 |
2016 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs4769874 (ALOX5AP), rs854560 (PON1), and rs4646903 (CYP1A1 MspI polymorphism) are significantly associated with an increased risk of CAD with respective odds ratios of 1.53703, 1.67710, and 1.35520; the genetic variant rs9579646 (ALOX5AP) is significantly associated with a decreased risk of CAD (OR 0.76163).
|
25902778 |
2015 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, PON1 Q192R polymorphism is significantly associated with susceptibility of CAD in the Chinese Han population, and the 192R allele might be an independent predictor for CAD.
|
24918121 |
2014 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PON1 Q192R can be used as the DNA marker test to evaluate the risk of CAD in postmenopausal Indian women with high ApoB.
|
23171143 |
2013 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study, thus, identifies the Q192R polymorphism as an additional risk factor for CAD in the Saudi population and suggests that it may have prognostic value.
|
23625196 |
2013 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the three SNPs, only the R allele of Q192R polymorphism was associated with CAD (p<0.05).
|
22750797 |
2012 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In view of the reported association of SNPs in the paraoxonase (PON1) gene with coronary artery disease (CAD), and the absence of conclusive data from India, we investigated the relationship of three SNPs at different loci (-108C/T, L55M and Q192R) of the PON1 gene and their haplotypes with CAD among people residing in the northern plains of India.
|
22750797 |
2012 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study.
|
21982484 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the clinical relevance of the PON1 Q192R genotype in a population of individuals with coronary artery disease who underwent stent implantation and received clopidogrel therapy.
|
21170047 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD.
|
21231776 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study will give an insight about the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM.
|
21438666 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The coding Q192R polymorphism, promoter -162A/G polymorphism and L-T-G-Q-C and L-T-G-R-G haplotypes are all independently associated with CAD.
|
21629682 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict CAD risk (Odds Ratio [OR] per R allele 0.98[0.84-1.15], p = 0.8).
|
19710913 |
2009 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results suggest that there is an association between the PON 1 L/M 55 polymorphism of paraoxonase and CAD in Turkish patients but not with PON 1 Q/R 192 polymorphism.
|
19226538 |
2009 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Only PON1 L55M (MM) genotype frequency was significantly higher in CAD patients than in controls (P<0.05), while its frequency was similar between the two subgroups according to CAD severity.
|
19269283 |
2009 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results suggest that there is an association between the PON 1 L/M 55 polymorphism of paraoxonase and CAD in Turkish patients but not with PON 1 Q/R 192 polymorphism.
|
19226538 |
2009 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the risk of CAD associated with PON1 Q192R and L55M polymorphisms in 298 CAD patients and 298 healthy individuals.
|
19280995 |
2008 |
|
rs854560
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the risk of CAD associated with PON1 Q192R and L55M polymorphisms in 298 CAD patients and 298 healthy individuals.
|
19280995 |
2008 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was an evaluation of a possible association between R192Q polymorphism of PON1 gene and CAD as well as interactions between polymorphic variants and conventional risk factors of CAD in determining the risk of the disease.
|
17560461 |
2007 |