| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | BEFREE | Association Between Paraoxonase 2 Ser311Cys Polymorphism and Coronary Heart Disease Risk: A Meta-Analysis. | 27609416 | 2016 |
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0.070 | GeneticVariation | BEFREE | We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. | 21231776 | 2011 |
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|
0.070 | GeneticVariation | BEFREE | However, we did not find any relationship between polymorphism 311Ser/Cys and CAD risk (P = .418). | 19939821 | 2010 |
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|
0.070 | GeneticVariation | BEFREE | The cases (coronary artery disease positive patients) showed significant differences in the distribution of cys 311 ser paraoxonase-2 genotypes as compared with the controls (coronary artery disease negative subjects, P=0.015). | 18759523 | 2008 |
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|
0.070 | GeneticVariation | BEFREE | We analyzed two common polymorphisms in PON1 (i.e., M/L55 and R/Q 192 mutations) and PON2 (i.e., G/A148 and C/S311 mutations) in 352 high-risk patients with angiographically defined CAD. | 14996478 | 2004 |
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|
0.070 | GeneticVariation | BEFREE | Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be associated with the risk of CAD in several European or European-derived populations. | 12454802 | 2003 |
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|
0.070 | GeneticVariation | BEFREE | Genotype distributions and allele frequencies of M/L55 and C/S311 were similar among the control and patient groups, whereas the R192 allele frequency was significantly higher (P<0.001) in CAD (75%) and ischemic stroke (76%) patients than in control subjects (65%). | 10729395 | 2000 |
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|
0.010 | GeneticVariation | BEFREE | We analyzed two common polymorphisms in PON1 (i.e., M/L55 and R/Q 192 mutations) and PON2 (i.e., G/A148 and C/S311 mutations) in 352 high-risk patients with angiographically defined CAD. | 14996478 | 2004 |