Gene: TLR4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE No association between rs4986790 and CAD risk was found. 30784241

2019
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility. 28793055

2017
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE No association between TLR2-Arg677Trp or TLR4-Asp299Gly and -Thr399Ile gene polymorphisms and the presence or the severity of CAD was observed. 25542811

2015
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for coronary artery disease, and increases a chance of longevity. 19273219

2009
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarction in a cohort of patients with angiographically documented coronary artery disease, and performed a meta-analysis using data sets from three independent studies. 15864121

2005
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. 15632890

2004
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE Among symptomatic men with documented coronary artery disease, the TLR4 Asp299Gly polymorphism was associated with the risk of cardiovascular events. 12742999

2003
dbSNP: rs4986790
rs4986790
TLR4
0.080 GeneticVariation BEFREE The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease. 12957699

2003
dbSNP: rs11536889
rs11536889
TLR4
0.030 GeneticVariation BEFREE The rs11536879 and rs11536889</span> polymorphisms of TLR4 gene and serum TLR4 protein levels may contribute to the occurrence and development of CAD. 31082501

2019
dbSNP: rs11536889
rs11536889
TLR4
0.030 GeneticVariation BEFREE Our results demonstrate that TLR4 rs11536889 polymorphism is a novel genetic factor in the development of CAD, influencing the extent and severity of CAD. 28002812

2017
dbSNP: rs11536889
rs11536889
TLR4
0.030 GeneticVariation BEFREE Thus, the novel interaction between TLR4 rs11536889 and MyD88 rs7744 was related with an increased risk of CAD, that could be strengthened by the presence of hyperglycemia or hyperlipidemia. 26959040

2016
dbSNP: rs4986791
rs4986791
TLR4
0.020 GeneticVariation BEFREE Our analysis suggests that rs4986791 is negatively associated with CAD risk in Asians but not in Caucasians. 30784241

2019
dbSNP: rs4986791
rs4986791
TLR4
0.020 GeneticVariation BEFREE No association between TLR2-Arg677Trp or TLR4-Asp299Gly and -Thr399Ile gene polymorphisms and the presence or the severity of CAD was observed. 25542811

2015
dbSNP: rs11536879
rs11536879
TLR4
0.010 GeneticVariation BEFREE The rs11536879</span> and rs11536889 polymorphisms of TLR4 gene and serum TLR4 protein levels may contribute to the occurrence and development of CAD. 31082501

2019