|
rs375874539
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our data showed that (1) the frequency of C609T NQO1 was significantly increased in TNM stage III HCC patients; (2) no significant association was found between p53 expression and C609T polymorphism of NQO1 gene; and (3) a tumor/non-tumor (T/N) ratio > 1.27 of NQO1 expression revealed by real-time qPCR analyses was positively correlated with poorer survival in patients with tumors >5 cm, suggesting that an increase of NQO1 expression may be an indicator of advanced tumor progression.
|
19688691 |
2009 |
|
rs1288373809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data showed that (1) the frequency of C609T NQO1 was significantly increased in TNM stage III HCC patients; (2) no significant association was found between p53 expression and C609T polymorphism of NQO1 gene; and (3) a tumor/non-tumor (T/N) ratio > 1.27 of NQO1 expression revealed by real-time qPCR analyses was positively correlated with poorer survival in patients with tumors >5 cm, suggesting that an increase of NQO1 expression may be an indicator of advanced tumor progression.
|
19688691 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population.
|
20309940 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population.
|
20309940 |
2011 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population.
|
20309940 |
2011 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC.
|
20538734 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma.
|
20886596 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma.
|
20886596 |
2011 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma.
|
20886596 |
2011 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21094160 |
2011 |
|
rs121912654
|
|
|
0.720 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21094160 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21616106 |
2011 |
|
rs121912654
|
|
|
0.720 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21616106 |
2011 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
HCC often harbors a TP53 (tumor protein p53) mutation at codon 249 (R249S).
|
21768053 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs121912656
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Furthermore, p53(G245D) was shown to have a similar pattern of subcellular localization to ZBP-89 in tissues of HCC patients in Hong Kong.
|
22214764 |
2012 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, these results support the preferential occurrence of R249S-mutated DNA in HCC developing in the absence of cirrhosis in a context of HBV chronic infection.
|
22675488 |
2012 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation.
|
22759751 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |