Our results suggest that SNP of rs1135519 modulates <i>miR-122</i> expression and contributes to the genetic susceptibility of HCC, either independently or together with rs9966765 in <i>miR-122.</i> Further well-designed studies with lager sample sizes are needed to confirm our findings.
Three selected SNPs in <i>miR-122</i> (rs9966765, rs1135519, and rs17669) were genotyped in 1050 HCC patients and 1079 cancer-free controls using Sequenom MassARRAY platform and the associations of the three SNPs and HCC risk were evaluated.