|
rs20417
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analyses stratified by ethnicity, the COX-2 -1195G/A, -765G/C, and +8473T/C were all associated with an increased HCC risk in Asian populations (rs689466 A vs. G: OR = 1.346, P = 0.001, 95% CI: 1.137-1.595, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.869; rs20417 CC vs. GG + GC: OR = 3.069, P = 0.013, 95% CI: 1.265-7.447; rs5275 CC vs. TT + TC: OR = 1.626, P = 0.020, 95% CI: 1.079-2.452, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.495).
|
29578159 |
2018 |
|
rs5275
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analyses stratified by ethnicity, the COX-2 -1195G/A, -765G/C, and +8473T/C were all associated with an increased HCC risk in Asian populations (rs689466 A vs. G: OR = 1.346, P = 0.001, 95% CI: 1.137-1.595, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.869; rs20417 CC vs. GG + GC: OR = 3.069, P = 0.013, 95% CI: 1.265-7.447; rs5275 CC vs. TT + TC: OR = 1.626, P = 0.020, 95% CI: 1.079-2.452, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.495).
|
29578159 |
2018 |
|
rs20417
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results showed that the Cox-2 rs20417 (-765 G/C) polymorphism was not associated with HCC risk in the studied genetic contrast modes (C vs. G, GC vs. GG, and CC + GC vs. GG).
|
25400773 |
2014 |
|
rs5275
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Similarly, no significant association of the Cox-2 rs5275 (+ 8473 T/C) polymorphism and HCC risk was found under any of the studied contrasts (C vs. T, TC vs. TT, CC vs. TT, CC + TC vs. TT, CC vs. TC + TT).
|
25400773 |
2014 |
|
rs20417
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated.
|
21042835 |
2011 |
|
rs5275
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated.
|
21042835 |
2011 |
|
rs689466
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the subgroup analyses stratified by ethnicity, the COX-2 -1195G/A, -765G/C, and +8473T/C were all associated with an increased HCC risk in Asian populations (rs689466 A vs. G: OR = 1.346, P = 0.001, 95% CI: 1.137-1.595, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.869; rs20417 CC vs. GG + GC: OR = 3.069, P = 0.013, 95% CI: 1.265-7.447; rs5275 CC vs. TT + TC: OR = 1.626, P = 0.020, 95% CI: 1.079-2.452, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.495).
|
29578159 |
2018 |
|
rs689466
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated.
|
21042835 |
2011 |
|
rs748500299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses of total included studies showed that there was an obvious association between COX-2 1195 G/A</span> polymorphism and HCC risk under two main genetic models (for AA versus GG, fixed-effects OR=1.45, 95 % CI 1.15-1.81, P=0.001, I (2) =0.0 %; for AA/GA versus GG, fixed-effects OR=1.26, 95 % CI 1.05-1.51, P=0.011, I (2) =0.0 %).
|
23494177 |
2013 |