| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.020 | GeneticVariation | BEFREE | We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. | 29333101 | 2018 |
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0.020 | GeneticVariation | BEFREE | Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at <i>AURKA</i> SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the <i>AURKA</i> gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC. | 29333101 | 2018 |
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0.020 | GeneticVariation | BEFREE | On the contrary, no significant association was found between Val57Ile and HBV-related HCC occurrence. | 28903390 | 2017 |
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0.020 | GeneticVariation | BEFREE | Our findings suggest that <i>AURKA</i> Ile31Phe</span> may play a role in mediating the susceptibility to HBV-related HCC among Chinese. | 28903390 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at <i>AURKA</i> SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the <i>AURKA</i> gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC. | 29333101 | 2018 |
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0.010 | GeneticVariation | BEFREE | We report on the association between 4 single nucleotide polymorphisms (SNPs) of the <i>AURKA</i> gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. | 29333101 | 2018 |
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0.010 | GeneticVariation | BEFREE | Our result obtained from the initial computational compilations suggests the strong chance of Aurora-A G325W mutation (rs11539196) to cause hepatocellular carcinoma. | 24722014 | 2014 |