Source: CURATED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17401966
rs17401966
KIF1B
0.900 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs2596542
rs2596542
MICA ; MICA-AS1
0.900 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs7574865
rs7574865
STAT4
G 0.900 GeneticVariation GWASCAT The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). 23242368

2013
dbSNP: rs7574865
rs7574865
STAT4
G 0.900 GeneticVariation GWASDB The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). 23242368

2013
dbSNP: rs2596542
rs2596542
MICA ; MICA-AS1
A 0.900 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011
dbSNP: rs2596542
rs2596542
MICA ; MICA-AS1
A 0.900 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011
dbSNP: rs17401966
rs17401966
KIF1B
A 0.900 GeneticVariation GWASCAT We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios. 20676096

2010
dbSNP: rs17401966
rs17401966
KIF1B
A 0.900 GeneticVariation GWASDB We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios. 20676096

2010
dbSNP: rs9275319
rs9275319 		A 0.850 GeneticVariation GWASDB The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49. 23242368

2013
dbSNP: rs9275319
rs9275319 		A 0.850 GeneticVariation GWASCAT The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49. 23242368

2013
dbSNP: rs9275572
rs9275572 		0.840 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs9275572
rs9275572 		A 0.840 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011
dbSNP: rs9275572
rs9275572 		A 0.840 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011
dbSNP: rs121913409
rs121913409
CTNNB1
A 0.820 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913409
rs121913409
CTNNB1
T 0.820 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913409
rs121913409
CTNNB1
G 0.820 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913409
rs121913409
CTNNB1
0.820 GeneticVariation UNIPROT

dbSNP: rs121913409
rs121913409
CTNNB1
T 0.820 CausalMutation CLINVAR

dbSNP: rs121913407
rs121913407
CTNNB1
C 0.810 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913413
rs121913413
CTNNB1
A 0.810 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913413
rs121913413
CTNNB1
T 0.810 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs4678680
rs4678680
LOC105377022
0.810 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs455804
rs455804
GRIK1
C 0.810 GeneticVariation GWASCAT The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. 22807686

2012
dbSNP: rs455804
rs455804
GRIK1
C 0.810 GeneticVariation GWASDB The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. 22807686

2012
dbSNP: rs9272105
rs9272105
HLA-DQA1
A 0.810 GeneticVariation GWASCAT GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. 22807686

2012