|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was no association between the D299G or T-1237C variants and uncomplicated or severe malaria using any of the genetic models tested.
|
28562749 |
2017 |
|
rs867186
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs867186-G variant was associated with increased sEPCR levels and sEPCR was lower in children with SM than CC (P < 0.001).
|
27255786 |
2016 |
|
rs12212067
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The FOXO3A variant rs12212067T>G was associated with the phenotype of severe malaria, but not with asymptomatic/mild malaria (allelic model: OR = 1.54, 95 % CI = 1.15-2.05, P = 0.0028; dominant model: OR = 1.94, 95 % CI = 1.36-2.77, P = 0.0002).
|
25421486 |
2015 |
|
rs867186
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs867186-GG genotype showed significant association with protection from severe malaria.
|
24635948 |
2014 |
|
rs12212067
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease susceptibility, is associated with a milder course of Crohn's disease and rheumatoid arthritis and with increased risk of severe malaria.
|
24035192 |
2013 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TLR-4-Asp299Gly and TLR-4-Thr399Ile conferred 1.5- and 2.6-fold increased risks of severe malaria, respectively.
|
16371473 |
2006 |
|
rs505151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the minor allele of the E670G PCSK9 polymorphism might be more susceptible to severe malaria.
|
29447211 |
2018 |
|
rs5744454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data not only reinstates that CD14 of TLR pathway plays a predominant role in P. falciparum malaria, it establishes a functional basis for genetic association of rs5744454 with P. falciparum severe malaria by demonstrating a cis-regulatory role of this promoter polymorphism.
|
30337251 |
2018 |
|
rs1128503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study also revealed the correlation between ABCB1 DNA promoter methylation with rs1128503 and rs2032582 polymorphisms in malaria and was related to increased expression of ABCB1 protein levels in complicated malaria group (p < 0.05) when compared to uncomplicated malaria and control groups.
|
28422980 |
2017 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study also revealed the correlation between ABCB1 DNA promoter methylation with rs1128503 and rs2032582 polymorphisms in malaria and was related to increased expression of ABCB1 protein levels in complicated malaria group (p < 0.05) when compared to uncomplicated malaria and control groups.
|
28422980 |
2017 |
|
rs1463502008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TREM1 rs2234237T variant causing the amino acid exchange Thr25Ser, which has been associated with higher TREM-1 plasma levels, was significantly more frequent among patients with severe malaria than in those with uncomplicated malaria (P = 0.036).
|
27671831 |
2016 |
|
rs2234237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TREM1 rs2234237T variant causing the amino acid exchange Thr25Ser, which has been associated with higher TREM-1 plasma levels, was significantly more frequent among patients with severe malaria than in those with uncomplicated malaria (P = 0.036).
|
27671831 |
2016 |
|
rs5743618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in TLR1 (I602S) and TLR6 (P249S) were genotyped by PCR-RFLP methods, and TLR2 (I/D) was genotyped by PCR in 200 samples each from uncomplicated malaria (UM) and severe malaria (SM).
|
26621243 |
2016 |
|
rs5743810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed the PP genotype of TLR6 (P249S) to be significantly more common in UM (P < 0.0001), whereas the 'SS' genotype was the risk factor for SM including its sub-clinical categories.
|
26621243 |
2016 |
|
rs8177374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study demonstrate that TIRAP S180L heterozygous mutation may protect patients against severe malaria and mortality.
|
27166096 |
2016 |
|
rs2069718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TA11CAG haplotype (rs2069705 T/C, rs2430561 A/T, rs3138557 (CA)n, rs2069718 T/C, rs2069727 A/G, rs2069728 G/A) carrying a short CA11 repeat also exhibited very strong association with severe malaria, particularly in the endemic region (severe vs. control, OR=14.56, 95% CI=3.39-85.81, P=3 × 10(-5)).
|
25445652 |
2015 |
|
rs2069727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TA11CAG haplotype (rs2069705 T/C, rs2430561 A/T, rs3138557 (CA)n, rs2069718 T/C, rs2069727 A/G, rs2069728 G/A) carrying a short CA11 repeat also exhibited very strong association with severe malaria, particularly in the endemic region (severe vs. control, OR=14.56, 95% CI=3.39-85.81, P=3 × 10(-5)).
|
25445652 |
2015 |
|
rs2069728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TA11CAG haplotype (rs2069705 T/C, rs2430561 A/T, rs3138557 (CA)n, rs2069718 T/C, rs2069727 A/G, rs2069728 G/A) carrying a short CA11 repeat also exhibited very strong association with severe malaria, particularly in the endemic region (severe vs. control, OR=14.56, 95% CI=3.39-85.81, P=3 × 10(-5)).
|
25445652 |
2015 |
|
rs2070874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control.
|
25935236 |
2015 |
|
rs3138557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TA11CAG haplotype (rs2069705 T/C, rs2430561 A/T, rs3138557 (CA)n, rs2069718 T/C, rs2069727 A/G, rs2069728 G/A) carrying a short CA11 repeat also exhibited very strong association with severe malaria, particularly in the endemic region (severe vs. control, OR=14.56, 95% CI=3.39-85.81, P=3 × 10(-5)).
|
25445652 |
2015 |
|
rs8179190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control.
|
25935236 |
2015 |
|
rs9282801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Long repeat alleles of the NOSII promoter microsatellite (CCTTT)n exhibited strong association with protection and the NOSII ATG haplotype (rs3729508, rs2297520, rs9282801) was strongly protective against severe malaria in both regions (endemic, severe vs. control, OR = 0.05, p = 0.0001; non-endemic, severe vs. control, OR = 0.3, p = 1 × 10(-5)).
|
26194693 |
2015 |
|
rs76723693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA samples from 135 children with severe malaria and 146 children with mild malaria from The Gambia were genotyped for the G6PD A- mutation that is most frequent among Gambians (G6PD 968 T->C); there was a marked deficiency of heterozygotes and an excess of homozygotes with severe malaria, producing a strong deviation from Hardy-Weinberg equilibrium.
|
24615128 |
2014 |
|
rs993269089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotypes that included DDX39B (-22C > G and -348C > T) and TNF polymorphisms were not directly associated with mild or complicated malaria infections; however, haplotypes AGC, ACC, GGT, AGT and ACT were associated with increased TNF levels.
|
25038626 |
2014 |
|
rs34383331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, diplotype (MIF-794CATT and rs34383331T > A) 5 T confers protection to severe malaria (OR = 0.55, p = 0.002) while 6A (OR = 3.07, p = 0.001) increases malaria risk.
|
24066864 |
2013 |