|
rs1057518939
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs386834061
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1042173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis.
|
31846848 |
2020 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49).
|
31846848 |
2020 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses.
|
30341786 |
2018 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses.
|
30341786 |
2018 |
|
rs376671742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of sequencing revealed a missense, heterozygous mutation of IL17F, converting a threonine to proline in a patient with RAS (T79P).
|
29458167 |
2018 |
|
rs4612666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.
|
29430721 |
2018 |
|
rs1143634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach.
|
28942153 |
2017 |
|
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach.
|
28942153 |
2017 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first study regarding CD40 gene rs4810485 and rs1883832 mutations investigated in RAS patients.
|
27875792 |
2017 |
|
rs4810485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis.
|
27875792 |
2017 |
|
rs3806265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering the high frequency of the presence of NLRP3 rs3806265 TT genotype in patients with RAS, it seems that this gene polymorphism could affect individual susceptibility to RAS.
|
26033552 |
2016 |
|
rs10759931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant association between TLR4 rs10759931 polymorphism and RAS.
|
25482673 |
2015 |
|
rs11697325
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant association between MMP-9 rs11697325 polymorphisms and RAS.
|
24118356 |
2014 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also number of oral ulcers was found to be associated with MTHFR C677T mutation in RAS patients.
|
23665953 |
2014 |
|
rs1805193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association of the A allele (Pcorr = 0.027), AA and AC genotypes (OR = 10.9 and 9.0, respectively) of the E-selectin rs5361 gene polymorphism and TAA haplotype (rs2205849, rs5361, and rs1805193, respectively; P = 0.03) with RAS.
|
23772946 |
2013 |
|
rs3743930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even if it is not statistically significant, the E148Q allele frequency was higher in patients with RAS than the control group.
|
23663176 |
2013 |
|
rs5361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first report to link inheritance of the A allele, AA and AC genotypes of the E-selectin rs5361 polymorphism with increased risk of RAS.
|
23772946 |
2013 |
|
rs10459953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no direct association was demonstrated between rs10459953 or rs1060822 and recurrent aphthous stomatitis, a strong linkage disequilibrium was identified between rs1060822 and rs2297518.
|
21481004 |
2011 |
|
rs1060822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no direct association was demonstrated between rs10459953 or rs1060822 and recurrent aphthous stomatitis, a strong linkage disequilibrium was identified between rs1060822 and rs2297518.
|
21481004 |
2011 |
|
rs2297518
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Inheritence of a NOS2 single-nucleotide polymorphism rs2297518 is associated with increased risk of recurrent aphthous stomatitis in a Jordanian population.
|
21481004 |
2011 |