|
rs10248566
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs1039229
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
GWASDB |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Interestingly, the normozoospermic males with the risk genotypes of rs12097821 and rs3129878 + rs10842262 + rs12097821 were observed to have higher total sperm counts relative to non-risk genotypes, suggesting that the risk alleles of the genetic loci may not be via impairing spermatogenic ability to express susceptibility to NOA.
|
25505198 |
2015 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs10910078
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs10978121
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs11135484
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results demonstrated that there was a suggestively significant interaction between Y-hg O3e(*) and rs11135484 on NOA (Pinter = 9.89 × 10(-5)).
|
27628680 |
2016 |
|
rs11204885
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs11754464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three low-frequency variants located at 6p22.2 (rs2298090 in HIST1H1E encoding p.Lys152Arg: OR = 0.30, P = 2.40 × 10(-16)) and 6p21.33 (rs200847762 in FKBPL encoding p.Pro137Leu: OR = 0.11, P = 3.77 × 10(-16); rs11754464 in MSH5: OR = 1.78, P = 3.71 × 10(-7)) associated with NOA risk after Bonferroni correction.
|
26199320 |
2015 |
|
rs11918142
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs11937871
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs11987150
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
GWASDB |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Interestingly, the normozoospermic males with the risk genotypes of rs12097821 and rs3129878 + rs10842262 + rs12097821 were observed to have higher total sperm counts relative to non-risk genotypes, suggesting that the risk alleles of the genetic loci may not be via impairing spermatogenic ability to express susceptibility to NOA.
|
25505198 |
2015 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs121908940
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs12429186
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs12614
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs13206743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We find strong evidence of three NOA susceptibility loci (P<5.0 × 10(-8)) at 6p21.32 (rs7194, P=3.76 × 10(-19)), 10q25.3 (rs7099208, P=6.41 × 10(-14)) and 6p12.2 (rs13206743, P=3.69 × 10(-8)), as well as one locus approaching genome-wide significance at 1q42.13 (rs3000811, P=7.26 × 10(-8)).
|
24852083 |
2014 |
|
rs1328626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for NOA in the Chinese population.
|
25463635 |
2015 |
|
rs1328641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs1328641 might influence testes development in the NOA patients.
|
25463635 |
2015 |
|
rs138178131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PGAM4 coding region mutations were not observed and the G75C polymorphism is not associated with NOA susceptibility among the Chinese Han population.
|
23631659 |
2013 |
|
rs140506267
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1406714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combined analysis using directly genotyped data for Stages 1 and 2 revealed that rs1406714 in CHD2 was associated with decreased risk of NOA [odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.68-0.89, Pmeta = 1.7E-04], whereas rs2126986 in GNAO1 and rs7226979 in BCL2 were both risk makers for NOA (rs2126986: OR = 1.28, 95% CI = 1.15-1.41, Pmeta = 2.3E-06; rs7226979: OR = 1.21, 95% CI = 1.11-1.33, Pmeta = 4.5E-05).
|
24549219 |
2014 |