|
rs3129878
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The case-control study strongly suggested a significant association between loci rs3129878, rs498422 and rs7194 and NOA (P = 6.75 × 10<sup>-21</sup> (OR = 2.2586), P = 0.0060 (OR = 1.4013) and P = 0.0128 (OR = 1.2626) respectively).
|
27597543 |
2017 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Interestingly, the normozoospermic males with the risk genotypes of rs12097821 and rs3129878 + rs10842262 + rs12097821 were observed to have higher total sperm counts relative to non-risk genotypes, suggesting that the risk alleles of the genetic loci may not be via impairing spermatogenic ability to express susceptibility to NOA.
|
25505198 |
2015 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Interestingly, the normozoospermic males with the risk genotypes of rs12097821 and rs3129878 + rs10842262 + rs12097821 were observed to have higher total sperm counts relative to non-risk genotypes, suggesting that the risk alleles of the genetic loci may not be via impairing spermatogenic ability to express susceptibility to NOA.
|
25505198 |
2015 |
|
rs2477686
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To better understand the role of the variants in conferring NOA risk, we selected four GWAS loci (HLA-DRA rs3129878, PRMT6 rs12097821, SOX5 rs10842262, and PEX10 rs2477686) that were reported before 2014 to investigate their association with NOA and their potential effects on sperm production in 1177 Han males from southwest China, including 545 patients with idiopathic NOA and 632 controls with normozoospermia.
|
25505198 |
2015 |
|
rs3129878
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Interestingly, the normozoospermic males with the risk genotypes of rs12097821 and rs3129878 + rs10842262 + rs12097821 were observed to have higher total sperm counts relative to non-risk genotypes, suggesting that the risk alleles of the genetic loci may not be via impairing spermatogenic ability to express susceptibility to NOA.
|
25505198 |
2015 |
|
rs3129878
|
|
|
0.720 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
GWASDB |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs10842262
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
GWASDB |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs12097821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs2477686
|
|
|
0.720 |
GeneticVariation |
GWASDB |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs2477686
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)).
|
22197933 |
2011 |
|
rs498422
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The case-control study strongly suggested a significant association between loci rs3129878, rs498422 and rs7194 and NOA (P = 6.75 × 10<sup>-21</sup> (OR = 2.2586), P = 0.0060 (OR = 1.4013) and P = 0.0128 (OR = 1.2626) respectively).
|
27597543 |
2017 |
|
rs498422
|
|
|
0.710 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs12614
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs16964657
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs17033369
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs2076531
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs2665969
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs3731611
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs7747521
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs7802723
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
|
22541561 |
2012 |
|
rs10248566
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs1039229
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs10910078
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |