|
rs28934571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gallbladder cancer does not appear associate with the R249S mutation in TP53.
|
28428144 |
2017 |
|
rs4986791
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thr399Ile also may be connected with gallbladder cancer, and both of these polymorphisms apparently have no impact on risk of prostate cancer.
|
21081146 |
2011 |
|
rs2228000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allelic association analysis for the two single-nucleotide polymorphisms (SNPs) showed that the risk allele T of Ala499Val was significantly associated with GBC [odds ratio (OR)=1.40, 95% confidence interval (CI): 1.11-1.76, P=0.005), with a population attributive risk of 5.3%.
|
21113018 |
2011 |
|
rs6259
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among women taking oral contraceptives, the effect of SHBG Ex8 + 6 (rs6259) on gallbladder cancer (OR = 6.7, 95% CI = 2.2-20.5; P interaction = 0.001) and stones (OR = 2.3, 95% CI = 1.1-4.9; P-interaction = 0.05) was statistically significant.
|
19168589 |
2009 |
|
rs4791171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APC rs11954856, GLI-1 rs2228226, and AXIN-2 rs4791171 were found to be associated with poor survival in advanced GBC patients.
|
26715268 |
2016 |
|
rs3834129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers for the "del" allele of rs3834129 SNP were associated with a 0.60-fold decreased risk for GBC (95% CI = 0.42-0.88; P(trend) = 0.005).
|
20564345 |
2010 |
|
rs11887534
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs743572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP17 rs743572 is associated with increased risk of GBC in tobacco users in the North Indian population.
|
24687554 |
2014 |
|
rs11954856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene-gene interaction using GMDR analysis predicted APC rs11954856 and AXIN2 rs4791171 as significant in conferring GBC susceptibility.
|
26715268 |
2016 |
|
rs2486758
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, the present study aimed to investigate the association of CYP17 (rs2486758, and rs743572) polymorphisms with GBC susceptibility.
|
24687554 |
2014 |
|
rs2234767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, the present study aimed to investigate the association of functional SNPs of DR4 (rs20575, rs20576 and rs6557634), FAS (rs2234767) and FASL (rs763110) with gallbladder cancer (GBC) risk.
|
24587306 |
2014 |
|
rs763110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, the present study aimed to investigate the association of functional SNPs of DR4 (rs20575, rs20576 and rs6557634), FAS (rs2234767) and FASL (rs763110) with gallbladder cancer (GBC) risk.
|
24587306 |
2014 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, Arg399Gln polymorphism and Arg-Gln haplotype comprising XRCC1 Arg194Trp and Arg399Gln polymorphisms conferred low risk for GBC susceptibility.
|
19266243 |
2009 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, Arg399Gln polymorphism and Arg-Gln haplotype comprising XRCC1 Arg194Trp and Arg399Gln polymorphisms conferred low risk for GBC susceptibility.
|
19266243 |
2009 |
|
rs746702110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, Arg399Gln polymorphism and Arg-Gln haplotype comprising XRCC1 Arg194Trp and Arg399Gln polymorphisms conferred low risk for GBC susceptibility.
|
19266243 |
2009 |
|
rs909629195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, LASP-1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in GBC.
|
26797416 |
2016 |
|
rs1157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant interaction model with GBC susceptibility and ALDH1A1 rs13959T>G with increased risk of grade 3-4 hematological toxicity.
|
26318430 |
2016 |
|
rs1126497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant interaction model with GBC susceptibility and ALDH1A1 rs13959T>G with increased risk of grade 3-4 hematological toxicity.
|
26318430 |
2016 |
|
rs13959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant interaction model with GBC susceptibility and ALDH1A1 rs13959T>G with increased risk of grade 3-4 hematological toxicity.
|
26318430 |
2016 |
|
rs2228001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
rs35463555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LXR-β genotypes (rs35463555) [GA + AA] and (rs2695121) [TC + CC] were associated with risk of GBC [OR = 1.46, p = 0.03; OR = 1.52, p = 0.01, respectively] as compared to healthy controls whereas LXR-α (rs7120118) was not associated with GBC risk.
|
23838803 |
2013 |
|
rs2695121
|
|
|
0.020 |
GeneticVariation |
BEFREE |
LXR-β genotypes (rs35463555) [GA + AA] and (rs2695121) [TC + CC] were associated with risk of GBC [OR = 1.46, p = 0.03; OR = 1.52, p = 0.01, respectively] as compared to healthy controls whereas LXR-α (rs7120118) was not associated with GBC risk.
|
23838803 |
2013 |
|
rs7120118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LXR-β genotypes (rs35463555) [GA + AA] and (rs2695121) [TC + CC] were associated with risk of GBC [OR = 1.46, p = 0.03; OR = 1.52, p = 0.01, respectively] as compared to healthy controls whereas LXR-α (rs7120118) was not associated with GBC risk.
|
23838803 |
2013 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC.
|
26947513 |
2016 |
|
rs752742313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC.
|
26947513 |
2016 |