Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Investigation of the association between C677T polymorphism of the MTHFR gene and plasma homocysteine level in recurrent fetal miscarriage. 31172624

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The purpose of the present study is to evaluate and understand the association of global and MTHFR gene specific methylation in preeclampsia and recurrent miscarriages in light of MTHFR C677T polymorphism. 30986448

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Comparison of two preventive treatments for patients with recurrent miscarriages carrying a C677T methylenetetrahydrofolate reductase mutation: 5-year experience. 28703660

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. 27525841

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial. 26630680

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our data points toward the multifactorial nature of the recurrent miscarriage as relative contribution of variant genotype of MTHFR C677T is only twofold and further decreased to only onefold, and MTHFD-1958 lost its significance upon meta-analysis. 23685927

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017). 17217367

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We determined (i) the prevalence of three thrombophilic mutations [factor V Leiden (FVL), prothrombin G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR) C677T] amongst 357 Caucasian couples with RM and 68 parous Caucasian couples with no history of miscarriage and (ii) the prospective outcome of untreated pregnancies amongst couples with RM in which either partner carried a thrombophilic mutation. 16431900

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The prevalence of FVL, FII G20210A and MTHFR C677T was compared in 108 women with three or more pregnancy losses either exclusively in the first trimester, or mixed first and second trimester losses, with the prevalence found in 82 fertile parous control women without miscarriages. 12042290

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Carriage of the mutant allele of the MTHFR C677T polymorphism is associated with elevated serum levels of homocysteine and idiopathic recurrent miscarriage. 12039122

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE 102 patients with two or more consecutive abortions and 128 women without miscarriage were analyzed for factor V Leiden mutation (FVL), prothrombin G20210A mutation (PTM), C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, glycoprotein IIIa (GPIIIa) C1565T polymorphism, and beta-fibrinogen G-455A polymorphism by polymerase chain reaction (PCR) techniques. 11506076

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our results suggest that the presence of factor V Leiden and prothrombin G20210A polymorphism, but not MTHFR C677T homozygosity, could be additional risk factors for recurrent miscarriages. 10655323

2000

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We conclude that the C677T MTHFR mutation is not a risk predictor in women with a history of early or late recurrent miscarriage. 10233370

1999

dbSNP: rs1188383936
rs1188383936
F2
0.050 GeneticVariation BEFREE The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. 27525841

2016

dbSNP: rs1188383936
rs1188383936
F2
0.050 GeneticVariation BEFREE We determined (i) the prevalence of three thrombophilic mutations [factor V Leiden (FVL), prothrombin G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR) C677T] amongst 357 Caucasian couples with RM and 68 parous Caucasian couples with no history of miscarriage and (ii) the prospective outcome of untreated pregnancies amongst couples with RM in which either partner carried a thrombophilic mutation. 16431900

2006

dbSNP: rs1188383936
rs1188383936
F2
0.050 GeneticVariation BEFREE The prevalence of FVL, FII G20210A and MTHFR C677T was compared in 108 women with three or more pregnancy losses either exclusively in the first trimester, or mixed first and second trimester losses, with the prevalence found in 82 fertile parous control women without miscarriages. 12042290

2002

dbSNP: rs1188383936
rs1188383936
F2
0.050 GeneticVariation BEFREE 102 patients with two or more consecutive abortions and 128 women without miscarriage were analyzed for factor V Leiden mutation (FVL), prothrombin G20210A mutation (PTM), C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, glycoprotein IIIa (GPIIIa) C1565T polymorphism, and beta-fibrinogen G-455A polymorphism by polymerase chain reaction (PCR) techniques. 11506076

2001

dbSNP: rs1188383936
rs1188383936
F2
0.050 GeneticVariation BEFREE Our results suggest that the presence of factor V Leiden and prothrombin G20210A polymorphism, but not MTHFR C677T homozygosity, could be additional risk factors for recurrent miscarriages. 10655323

2000

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE The aim of this study was to investigate the association between of MTHFR C677T, A1298C, F2G20210A, and F5 G1691A genetic variants among Iranian women with recurrent miscarriage. 31317253

2019

dbSNP: rs899127658
rs899127658
F2
0.040 GeneticVariation BEFREE The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. 27525841

2016

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial. 26630680

2015

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE The aim of this study was to investigate the association between MTHFR C677T, A1298C, MTHFD G1958A and plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism among first trimester recurrent miscarriages. 23685927

2013

dbSNP: rs397507444
rs397507444
0.040 GeneticVariation BEFREE There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017). 17217367

2007

dbSNP: rs899127658
rs899127658
F2
0.040 GeneticVariation BEFREE Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages. 16138341

2005

dbSNP: rs899127658
rs899127658
F2
0.040 GeneticVariation BEFREE We hypothesized that the thrombophilic G1691A factor V Leiden gene mutation was a common significant cause of sporadic first trimester miscarriage. 16154434

2005