DisGeNET - a database of gene-disease associations

Malignant neoplasm of colon and/or rectum, C4722085

Gene: MIR149 ×

Source: BEFREE ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2292832

GPC1 ; MIR149 ; LOC100130449

0.030

GeneticVariation

BEFREE

Mir-149 rs2292832 may modulate the risk of gastrointestinal tract cancers especially colorectal cancer.

30930933

2019

dbSNP:

rs2292832

GPC1 ; MIR149 ; LOC100130449

0.030

GeneticVariation

BEFREE

Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown.

22161766

2012

dbSNP:

rs2292832

GPC1 ; MIR149 ; LOC100130449

0.030

GeneticVariation

BEFREE

Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48-1.02) in males.

21976437

2012