|
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Breast Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.
|
29520040 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
|
29326435 |
2019 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
|
30643258 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
|
29942086 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.
|
29186694 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Neuropathological characterization of a novel TANK binding kinase (TBK1) gene loss of function mutation associated with amyotrophic lateral sclerosis.
|
31498468 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
A large number of mutations in optineurin and optineurin-interacting proteins TANK-binding kinase (TBK1) and p62/SQSTM-1 have been found in the ALS patients, suggesting a common neuroprotective pathway.
|
28456633 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
<i>TANK-binding kinase 1</i> (<i>TBK1</i>) gene has been recently identified as a causative gene of amyotrophic lateral sclerosis (ALS).
|
28822984 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Surprisingly, a mutation in the OPTN interacting protein, i.e., the duplication of TANK binding protein 1 (TBK1) gene, also can cause both NTG and ALS.
|
27693724 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Missense and frameshift mutations in TRAF family member-associated NF-kappa-B activator (TANK)-binding kinase 1 (TBK1) have been reported in European sporadic and familial amyotrophic lateral sclerosis (ALS) cohorts.
|
26350399 |
2015 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In this study, we functionally and molecularly investigated TINKs and TANKs from blood and tissue samples of patients with colorectal cancer (CRC), a neoplasm in which inflammation and angiogenesis have clinical relevance, and compared them to NK cells from controls and patients with nononcologic inflammatory bowel disease.
|
29763380 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
Biomarker
|
disease |
BEFREE |
Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.
|
28069801 |
2017 |
|
Low Tension Glaucoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Surprisingly, a mutation in the OPTN interacting protein, i.e., the duplication of TANK binding protein 1 (TBK1) gene, also can cause both NTG and ALS.
|
27693724 |
2016 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The activation of TRAF-1 and TRAF-2 may be early events in the pathogenesis of IBD and their functions are not quite the same.
|
23414308 |
2013 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on these data, it is hypothesized that ZC3H15 may interact with TRAF-2 functionally within the NF-κB pathway, and may be explored as a potential target in AML.
|
23624947 |
2013 |
|
Low Tension Glaucoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Testing cohorts of NTG and normal controls for disease-causing mutations in TANK, identified a total of nine unique variants including three non-synonymous changes, one synonymous changes and five intronic changes.
|
23286385 |
2013 |
|
Psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our data indicate that TANK and CARMA2sh regulate TLR3 signaling in human keratinocytes, which could play a role in the pathophysiology of psoriasis.
|
31486084 |
2020 |
|
Alloimmunisation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among others, SNPs in TLR1/TANK and MALT1 were associated with a higher alloimmunization risk, while SNPs in STAM/IFNAR1 and STAT4 conferred a lower alloimmunization risk.
|
31168801 |
2019 |