HDAC6, histone deacetylase 6, 10013

N. diseases: 288; N. variants: 1
Disease: Polycystic Kidney Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.240 Biomarker group BEFREE Panobinostat and all three HDAC6 inhibitors decreased hepatorenal cystogenesis in PCK rats. 29366679 2018
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.240 Biomarker group BEFREE Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca<sup>2+</sup> in knock-out mouse models of polycystic kidney disease. 28887310 2017
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.240 AlteredExpression group BEFREE An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease. 28747357 2017
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.240 Biomarker group BEFREE Here we studied the effect of tubacin, a specific HDAC6 inhibitor, on cyst growth in polycystic kidney disease. 27165822 2016
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.240 Therapeutic group RGD HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis. 24434010 2014