HDAC6, histone deacetylase 6, 10013

N. diseases: 288; N. variants: 1
Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease BEFREE Herein, we examined the role of the cytoplasmic histone deacetylase, HDAC6, in regulating EC Toll-like receptor 4 (TLR4) signaling and modulating sepsis-induced lung injury in a neonatal model of sterile sepsis. 31268348 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease BEFREE We have found earlier that Tubastatin A (TubA), a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival in a mouse model of lethal cecal ligation and puncture (CLP)-induced sepsis. 30047002 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 AlteredExpression disease BEFREE Hdac6-/- mice display low serum levels of inflammatory cytokine IL-6 and correspondingly an increased survival to a systemic infection with Lm. 29281743 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease BEFREE Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. 28052874 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease RGD Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. 20538901 2010