HDAC6, histone deacetylase 6, 10013

N. diseases: 288; N. variants: 1
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE Our results suggest that inhibition of HDAC6 improves established cisplatin-induced cognitive deficits by the restoration of mitochondrial and synaptic impairments. 31571096 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. 30270813 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 AlteredExpression disease BEFREE Expression of HDAC6, an α-tubulin deacetylase, was reduced in the hippocampus in rats with cognitive impairment. 29613911 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE In the present study, we tested the potential of two selective HDAC6 inhibitors, tubastatin A and ACY-1215, to rescue cognitive deficits in a mouse model of AD. 24844691 2014
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE Thus, our study suggests that targeting HDAC6 could be a suitable strategy to ameliorate cognitive decline observed in AD. 23184605 2013