HDAC6, histone deacetylase 6, 10013

N. diseases: 288; N. variants: 1
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 Biomarker disease BEFREE Here, we show that inhibition of HDAC6 synergizes with anti-PD-L1 immune checkpoint blockade in ARID1A-inactivated ovarian cancer. 31311810 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 GeneticVariation disease BEFREE A key HDAC6 dependency of ARID1A-mutated ovarian cancer. 28752851 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 AlteredExpression disease BEFREE Here, we show that HDAC6 activity is essential in ARID1A-mutated ovarian cancers. 28737768 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 Biomarker disease CTD_human Our results suggest the elevation of both the proteasomal and alternate HDAC6-dependent proteolytic pathways in ovarian cancer and the potential of combined inhibition of proteasome and HDAC6 as a therapy for ovarian cancer. 19010849 2008