Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, CD24 genetic variants, including single-nucleotide polymorphisms and deletions, are etiologically relevant to autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.
|
25666875 |
2016 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.
|
26718436 |
2015 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conversely, the 1056 A>G and 1626 A>G polymorphisms were not found to be associated with MS. We conclude that the CD24 226 C>T polymorphism increases the risk of MS, while the 1527-1528 TG>del polymorphism seems to have a protective role against MS, suggesting that these two polymorphisms can be used as predictive biomarkers for MS development.
|
26039238 |
2015 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicates that CD24 P266-C/T polymorphism is more associated with the risk of MS than healthy controls.
|
25942344 |
2015 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that the CD24 Ala57Val polymorphism is associated with an increased risk of MS in Caucasians.
|
25830931 |
2015 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The correlation between MS severity score (MSSS), OCB status, CD24 genotype and IgG index was studied.
|
22262195 |
2012 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association between P226 polymorphisms (T/C), P1056 (A/G), P1527 (TG/del) and P1626 (A/G) of the CD24 gene and MS, comparing allele and genotype frequencies of patients versus controls.
|
21641619 |
2011 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that the CD24(v/v) genotype influences both MS disease risk and severity in Iranian MS patients, and the high disease severity in CD24(v/v) patients may indicate that they require more aggressive treatment than do patients carrying CD24(a/a).
|
21815873 |
2011 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data revealed that the susceptibility and the progression of MS in individuals with the CD24V/V genotype were greater than in those with the CD24A/V and CD24A/A genotypes.
|
19896210 |
2009 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analyses revealed that a dinucleotide deletion at position 1527 approximately 1528 (P1527(del)) from the CD24 mRNA translation start site is associated with a significantly reduced risk (odds ratio = 0.54 with 95% confidence interval = 0.34-0.82) and delayed progression (p = 0.0188) of MS.
|
17411341 |
2007 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because CD24 is increased drastically on resident cells in the CNS during EAE, our data have important implications for CD24-targeted therapy of MS.
|
17475850 |
2007 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Our analyses revealed that a dinucleotide deletion at position 1527 approximately 1528 (P1527(del)) from the CD24 mRNA translation start site is associated with a significantly reduced risk (odds ratio = 0.54 with 95% confidence interval = 0.34-0.82) and delayed progression (p = 0.0188) of MS.
|
17411341 |
2007 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population.
|
16900767 |
2006 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported.
|
16631259 |
2006 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The allele C in the CD24 gene has been related to multiple sclerosis (MS).
|
16900767 |
2006 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigate the contribution of CD24 to MS by studying single-nucleotide polymorphism in the ORF among 242 MS patients and 207 population controls.
|
14657362 |
2003 |