HDAC5, histone deacetylase 5, 10014

N. diseases: 114; N. variants: 4
Disease: Abnormal behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.020 Biomarker phenotype BEFREE The same effect was not observed for HDAC5+/- mice experiencing EST, suggesting that only ESI induces behavioral changes by acting precisely through HDAC5-related biological pathways. 28025089 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.020 AlteredExpression phenotype BEFREE Together, our findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes. 22243750 2012